Identification of Glioblastoma Phosphotyrosine-Containing Proteins with Two-Dimensional Western Blotting and Tandem Mass Spectrometry

Figure 4

Significant signaling pathway networks mined from phosphotyrosine-containing proteins in a glioblastoma tissue. Significant signaling pathway networks that are involved in human glioblastoma phosphotyrosine-containing proteins and that function in (a) cancer, organismal injury and abnormalities, reproductive system disease, and developmental disorder (merged Networks 1 and 3 in the Supplemental Table 3) and (b) cell morphology, cellular assembly and organization, cellular function, and maintenance (Network 2). A black solid edge denotes a direct relationship between two nodes (molecules: proteins; genes). A black unsolid edge denotes an indirect relationship between two nodes (molecules: proteins; genes). The various shapes of nodes denote the different functions. A curved line means intracellular translocation; a curved arrow means extracellular translocation.

(a)

(b)