Research Article

Identification of Glioblastoma Phosphotyrosine-Containing Proteins with Two-Dimensional Western Blotting and Tandem Mass Spectrometry

Table 3

The functional categories of phosphotyrosine-containing proteins identified by GO analysis.

CategoryTermCount ValuePhosphotyrosine-containing proteins

Annotation cluster 1
 INTERPROHeat shock protein Hsp90, conserved site31.66  − 05HS90A, HS90B, TRAP1
 SP_PIR_KEYWORDSStress response46.51  − 05HS90A, HSP71, HS90B, TRAP1
 PIR_SUPERFAMILYHeat shock protein, HSP90/HTPG types31.04  − 04HS90A, HS90B, TRAP1
 INTERPROHeat shock protein Hsp9031.09  − 04HS90A, HS90B, TRAP1
 SP_PIR_KEYWORDSNucleotide-binding95.06  − 04HS90A, HSP71, TBA1A, HS90B, TBA1B, ACTB, TBA8, ACTBL, TRAP1
 SMARTHATPase_c36.82  − 04HS90A, HS90B, TRAP1
 GOTERM_MF_FATUnfolded protein binding46.91  − 04HS90A, HSP71, HS90B, TRAP1
 INTERPROATP-binding region, ATPase-like37.08  − 04HS90A, HS90B, TRAP1
 SP_PIR_KEYWORDSChaperone48.54  − 04HS90A, HSP71, HS90B, TRAP1
 GOTERM_MF_FATNucleotide binding100.003658702HS90A, HSP71, TBA1A, HS90B, TBA1B, ACTB, LDHB, TBA8, ACTBL, TRAP1
 GOTERM_MF_FATPurine ribonucleotide binding90.004063562HS90A, HSP71, TBA1A, HS90B, TBA1B, ACTB, TBA8, ACTBL, TRAP1
 GOTERM_MF_FATRibonucleotide binding90.004063562HS90A, HSP71, TBA1A, HS90B, TBA1B, ACTB, TBA8, ACTBL, TRAP1
 GOTERM_BP_FATResponse to unfolded protein30.004383705HS90A, HSP71, HS90B
 GOTERM_MF_FATPurine nucleotide binding90.005349089HS90A, HSP71, TBA1A, HS90B, TBA1B, ACTB, TBA8, ACTBL, TRAP1
 GOTERM_BP_FATResponse to protein stimulus30.009707935HS90A, HSP71, HS90B
 KEGG_PATHWAYAntigen processing and presentation30.018271588HS90A, HSP71, HS90B
 SP_PIR_KEYWORDSATP-binding60.018307877HS90A, HSP71, HS90B, ACTB, ACTBL, TRAP1
 GOTERM_BP_FATProtein folding30.025155073HS90A, HS90B, TRAP1
Annotation Cluster 2
 INTERPROAlpha tubulin35.96  − 05TBA1A, TBA1B, TBA8
 KEGG_PATHWAYPathogenic Escherichia coli infection43.53  − 04TBA1A, TBA1B, ACTB, TBA8
 INTERPROTubulin/FtsZ, 2-layer sandwich domain33.78  − 04TBA1A, TBA1B, TBA8
 INTERPROTubulin, conserved site34.14  − 04TBA1A, TBA1B, TBA8
 INTERPROTubulin34.51  − 04TBA1A, TBA1B, TBA8
 INTERPROTubulin/FtsZ, GTPase domain34.51  − 04TBA1A, TBA1B, TBA8
 PIR_SUPERFAMILYTubulin30.001118145TBA1A, TBA1B, TBA8
 GOTERM_BP_FATCellular protein complex assembly40.001418705HS90A, TBA1A, TBA1B, TBA8
 GOTERM_BP_FATMacromolecular complex assembly60.001848247HS90A, TBA1A, TBA1B, ANXA5, TBA8, APOA1
 GOTERM_BP_FATProtein polymerization30.002113041TBA1A, TBA1B, TBA8
 GOTERM_BP_FATMacromolecular complex subunit organization60.002466419HS90A, TBA1A, TBA1B, ANXA5, TBA8, APOA1
 GOTERM_BP_FATProtein complex assembly50.004757666HS90A, TBA1A, TBA1B, ANXA5, TBA8
 GOTERM_BP_FATProtein complex biogenesis50.004757666HS90A, TBA1A, TBA1B, ANXA5, TBA8
 GOTERM_MF_FATStructural constituent of cytoskeleton30.005698133GFAP, TBA1B, ACTB
 GOTERM_BP_FATCellular macromolecular complex assembly40.009429911HS90A, TBA1A, TBA1B, TBA8
 GOTERM_BP_FATMicrotubule-based movement30.010778579TBA1A, TBA1B, TBA8
 GOTERM_CC_FATCytoskeleton70.012358854CE192, TBA1A, GFAP, TBA1B, ACTB, TBA8, ACTBL
 GOTERM_BP_FATCellular macromolecular complex subunit organization40.012902263HS90A, TBA1A, TBA1B, TBA8
 GOTERM_MF_FATStructural molecule activity50.014607667TBA1A, GFAP, TBA1B, ACTB, TBA8
 KEGG_PATHWAYGap junction30.02084525TBA1A, TBA1B, TBA8
 SP_PIR_KEYWORDSMicrotubule30.030784033TBA1A, TBA1B, TBA8
 GOTERM_MF_FATGTPase activity30.041221688TBA1A, TBA1B, TBA8
 GOTERM_CC_FATMicrotubule cytoskeleton40.045760129CE192, TBA1A, TBA1B, TBA8
 GOTERM_CC_FATCytoskeletal part50.048220584CE192, TBA1A, GFAP, TBA1B, TBA8
 GOTERM_BP_FATMicrotubule-based process30.048340219TBA1A, TBA1B, TBA8
 UP_SEQ_FEATURENucleotide phosphate-binding region:GTP30.048546013TBA1A, TBA1B, TBA8
Annotation Cluster 3
 GOTERM_CC_FATMelanosome30.007590334HS90A, HS90B, 1433E
 GOTERM_CC_FATPigment granule30.007590334HS90A, HS90B, 1433E
 GOTERM_MF_FATProtein domain specific binding40.013570111HS90A, TBA1A, HS90B, 1433E
 GOTERM_CC_FATCytoplasmic membrane-bounded vesicle40.045968066HS90A, HS90B, 1433E, APOA1
 GOTERM_CC_FATMembrane-bounded vesicle40.049793741HS90A, HS90B, 1433E, APOA1
Annotation Cluster 4
 SP_PIR_KEYWORDSDisease mutation70.009381239HEXA, TBA1A, GFAP, ACTB, PRP8, LDHB, APOA1