Comparative Study of the Accuracy of Different Techniques for the Laboratory Diagnosis of Schistosomiasis Mansoni in Areas of Low Endemicity in Barra Mansa City, Rio de Janeiro State, Brazil

Table 7

Description of the sensitivity, specificity, the positive likelihood ratio, the negative likelihood ratio, the positive predictive value, and the negative predictive value of all diagnostic techniques compared to the COPT technique in individuals from the city of Barra Mansa, RJ, 2011.

Techniques	Parameters	Estimate	IC (95%)
			Lower	Higher
KK-HH	Sensitivity (%)	13.8	3.9	31.7
	Specificity (%)	99.8	99.0	100.0
	Likelihood ratio (+)	74.9	8.6	649.0
	Likelihood ratio (−)	0.9	0.7	1.0
	Positive predictive value (PPV) (%)	80.0	28.4	99.5
	Negative predictive value (NPV) (%)	95.6	93.6	97.1
	Accuracy (%)	95.5	95.1	95.8
ELISA-IgG	Sensitivity (%)	66.7	48.2	82.0
	Specificity (%)	91.5	89.0	93.7
	Likelihood ratio (+)	7.9	5.5	11.3
	Likelihood ratio (−)	0.4	0.2	0.6
	Positive predictive value (PPV) (%)	31.0	20.5	43.1
	Negative predictive value (NPV) (%)	98.0	96.4	99.0
	Accuracy (%)	90.2	89.5	90.9
ELISA-IgM	Sensitivity (%)	81.8	64.5	93.0
	Specificity (%)	82.0	78.7	85.1
	Likelihood ratio (+)	4.6	3.6	5.8
	Likelihood ratio (−)	0.2	0.1	0.4
	Positive predictive value (PPV) (%)	20.6	14.0	28.6
	Negative predictive value (NPV) (%)	98.8	97.3	99.5
	Accuracy (%)	82.0	80.9	83.2
IFT-IgM	Sensitivity (%)	78.8	61.1	91.0
	Specificity (%)	87.7	84.8	90.3
	Likelihood ratio (+)	6.4	4.9	8.5
	Likelihood ratio (−)	0.2	0.1	0.5
	Positive predictive value (PPV) (%)	26.8	18.3	36.8
	Negative predictive value (NPV) (%)	98.6	97.2	99.5
	Accuracy (%)	87.3	86.4	88.1
qPCR-feces	Sensitivity (%)	51.7	32.5	70.6
	Specificity (%)	92.6	90.1	94.7
	Likelihood ratio (+)	7.0	4.4	11.1
	Likelihood ratio (−)	0.5	0.3	0.8
	Positive predictive value (PPV) (%)	27.3	16.1	41.0
	Negative predictive value (NPV) (%)	97.3	95.5	98.5
	Accuracy (%)	90.6	89.9	91.3
qPCR-serum	Sensitivity (%)	12.1	3.4	28.2
	Specificity (%)	99.1	98	99.7
	Likelihood ratio (+)	14.0	4.0	49.8
	Likelihood ratio (−)	0.9	0.8	1.0
	Positive predictive value (PPV) (%)	44.4	13.7	78.8
	Negative predictive value (NPV) (%)	95.2	93.2	96.8
	Accuracy (%)	94.4	94	94.9