Review Article
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis
Table 1
Characteristics of major human and murine mast cell proteases.
| | Protein designation | Mast cell subtype | Chromosomal location | Gene name | Primary substrate specificity | Subunit structure |
| | Chymase |
| | Human | | Chymase (CMA1) | MCTC | 14q11.2 | CMA1 | Chymotrypsin-like (aromatic amino acid) | Monomer |
| | Mouse | | mMCP-1 | MMC | 14C1/2 | Mcpt1 | Chymotrypsin-like (aromatic amino acid) | Monomer | | mMCP-2 | MMC | 14C1/2 | Mcpt2 | Unknown (low enzymatic activity) | Monomer | | mMCP-4 | CTMC | 14C1/2 | Mcpt4 | Chymotrypsin-like (aromatic amino acid) | Monomer | | mMCP-5 | CTMC | 14C1/2 | Cma1/Mcpt5 | Elastase-like (Val/Ala/Ile) | Monomer |
| | Tryptase |
| | Human | | Tryptase βII/βIII (human) | MCTC/MCT | 16p13.3 | TPSB2 | Trypsin-like (Arg/Lys) | Tetramer | | Tryptase αI/βI (human) | MCTC/MCT | 16p13.3 | TPSAB1 | Trypsin-like (Arg/Lys) | Tetramer |
| | Mouse | | mMCP-6 | CTMC | 17A3.3 | Mcpt6 | Trypsin-like (Arg/Lys) | Tetramer | | mMCP-7 | CTMC | 17A3.3 | Tpsab1 | Trypsin-like (Arg/Lys) | Tetramer |
| | Carboxypeptidase A3 |
| | Human | | MC-CPA | MCTC | 3q24 | CPA3 | CPA-like
(C-terminal aromatic/aliphatic amino acids) | Monomer |
| | Mouse | | MC-CPA | CTMC | 3A3 | Cpa3 | CPA-CPA-like
(C-terminal aromatic/aliphatic amino acids) | Monomer |
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