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BioMed Research International
Volume 2015 (2015), Article ID 143720, 12 pages
http://dx.doi.org/10.1155/2015/143720
Review Article

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

1Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan
2National Environmental Health Research Center, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan

Received 16 December 2014; Accepted 19 February 2015

Academic Editor: Il Je Yu

Copyright © 2015 Yueh-Hsia Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.