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BioMed Research International
Volume 2015 (2015), Article ID 153437, 7 pages
http://dx.doi.org/10.1155/2015/153437
Clinical Study

The Association between Cerebral White Matter Lesions and Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acids Ratio to Cognitive Impairment Development

1Department of Cardiology, Hokusetsu General Hospital, Takatsuki, Osaka 569-8585, Japan
2Department of Radiology, Hokusetsu General Hospital, Takatsuki, Osaka 569-8585, Japan
3Department of Rehabilitation, Aijinkai Rehabilitation Hospital, Takatsuki, Osaka, Japan

Received 12 February 2015; Revised 20 May 2015; Accepted 31 May 2015

Academic Editor: Charles Ramassamy

Copyright © 2015 Michihiro Suwa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F.-E. De Leeuw, J. C. de Groot, E. Achten et al., “Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam scan study,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 70, no. 1, pp. 9–14, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. S. E. Vermeer, T. den Heijer, P. J. Koudstaal, M. Oudkerk, A. Hofman, and M. M. B. Breteler, “Incidence and risk factors of silent brain infarcts in the population-based Rotterdam scan study,” Stroke, vol. 34, no. 2, pp. 392–396, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. E. J. Van Dijk, N. D. Prins, H. A. Vrooman, A. Hofman, P. J. Koudstaal, and M. M. B. Breteler, “Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences. Rotterdam scan study,” Stroke, vol. 39, no. 10, pp. 2712–2719, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. W. M. van der Flier, E. C. W. van Straaten, F. Barkhof et al., “Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study,” Stroke, vol. 36, no. 10, pp. 2116–2120, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. L. C. Silbert, D. B. Howieson, H. Dodge, and J. A. Kaye, “Cognitive impairment risk: white matter hyperintensity progression matters,” Neurology, vol. 73, no. 2, pp. 120–125, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. N. D. Prins, E. J. van Dijk, T. den Heijer et al., “Cerebral white matter lesions and the risk of dementia,” Archives of Neurology, vol. 61, no. 10, pp. 1531–1534, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Chowdhury, S. Stevens, D. Gorman et al., “Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis,” British Medical Journal, vol. 345, no. 7881, Article ID e6698, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. J. K. Virtanen, D. S. Siscovick, W. T. Longstreth Jr., L. H. Kuller, and D. Mozaffarian, “Fish consumption and risk of subclinical brain abnormalities on MRI in older adults,” Neurology, vol. 71, no. 6, pp. 439–446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Yokoyama, H. Origasa, M. Matsuzaki et al., “Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis,” The Lancet, vol. 369, no. 9567, pp. 1090–1098, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Tanaka, Y. Ishikawa, M. Yokoyama et al., “Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial,” Stroke, vol. 39, no. 7, pp. 2052–2058, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. B. M. van Gelder, M. Tijhuis, S. Kalmijn, and D. Kromhout, “Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen elderly study,” The American Journal of Clinical Nutrition, vol. 85, no. 4, pp. 1142–1147, 2007. View at Google Scholar · View at Scopus
  12. M. Hashimoto and S. Hossain, “Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease,” Journal of Pharmacological Sciences, vol. 116, no. 2, pp. 150–162, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Bauer, M. Hughes, R. Rowsell et al., “Omega-3 supplementation improves cognition and modifies brain activation in young adults,” Human Psychopharmacology: Clinical and Experimental, vol. 29, no. 2, pp. 133–144, 2014. View at Publisher · View at Google Scholar
  14. Y. Shinohara, H. Tohgi, S. Hirai et al., “Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA study): 1. Design and results at enrollment,” Cerebrovascular Diseases, vol. 24, no. 2-3, pp. 202–209, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Fukuda and M. Kitani, “Differences between treated and untreated hypertensive subjects in the extent of periventricular hyperintensities observed on brain MRI,” Stroke, vol. 26, no. 9, pp. 1593–1597, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. R. A. Whitmer, S. Sidney, J. Selby, S. C. Johnston, and K. Yaffe, “Midlife cardiovascular risk factors and risk of dementia in late life,” Neurology, vol. 64, no. 2, pp. 277–281, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Deschaintre, F. Richard, D. Leys, and F. Pasquier, “Treatment of vascular risk factors is associated with slower decline in Alzheimer disease,” Neurology, vol. 73, no. 9, pp. 674–680, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. P. B. Gorelick, A. Scuteri, S. E. Black et al., “Vascular contributions to cognitive impairment and dementia. A statement for healthcare professionals from the American Heart Association/American Stroke Association,” Stroke, vol. 42, no. 9, pp. 2672–2713, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. R. N. Kalaria, “Cerebrovascular disease and mechanisms of cognitive impairment: evidence from clinicopathological studies in humans,” Stroke, vol. 43, no. 9, pp. 2526–2534, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. D. A. Snowdon, L. H. Greiner, J. A. Mortimer, K. P. Riley, P. A. Greiner, and W. R. Markesbery, “Brain infarction and the clinical expression of Alzheimer disease. The Nun Study,” Journal of the American Medical Association, vol. 277, no. 10, pp. 813–817, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. C. K. Suemoto, R. Nitrini, L. T. Grinberg et al., “Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries,” Stroke, vol. 42, no. 12, pp. 3614–3615, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. C. R. Wendell, S. R. Waldstein, L. Ferrucci, R. J. O'Brien, J. B. Strait, and A. B. Zonderman, “Carotid atherosclerosis and prospective risk of dementia,” Stroke, vol. 43, no. 12, pp. 3319–3324, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Iso, K. M. Rexrode, M. J. Stampfer et al., “Intake of fish and omega-3 fatty acids and risk of stroke in women,” The Journal of the American Medical Association, vol. 285, no. 3, pp. 304–312, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Mita, H. Watada, T. Ogihara et al., “Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes,” Atherosclerosis, vol. 191, no. 1, pp. 162–167, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Sekikawa, T. Kadowaki, A. El-Saed et al., “Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness,” Stroke, vol. 42, no. 9, pp. 2538–2543, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. Tully, H. M. Roche, R. Doyle et al., “Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study,” British Journal of Nutrition, vol. 89, no. 4, pp. 483–489, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Mozaffarian and J. H. Y. Wu, “Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events,” Journal of the American College of Cardiology, vol. 58, no. 20, pp. 2047–2067, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. R. De Caterina, “Drug therapy: n-3 fatty acids in cardiovascular disease,” The New England Journal of Medicine, vol. 364, no. 25, pp. 2439–2450, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Kromhout, S. Yasuda, J. M. Geleijnse, and H. Shimokawa, “Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work?” European Heart Journal, vol. 33, no. 4, pp. 436–443, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Sundler, D. Winstedt, and J. Wijkander, “Acyl-chain selectivity of the 85 kDa phospholipase A2 and of the release process in intact macrophages,” Biochemical Journal, vol. 301, no. 2, pp. 455–458, 1994. View at Google Scholar · View at Scopus
  31. T. Ninomiya, M. Nagata, J. Hata et al., “Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama study,” Atherosclerosis, vol. 231, no. 2, pp. 261–267, 2013. View at Publisher · View at Google Scholar
  32. A. L. Cawood, R. Ding, F. L. Napper et al., “Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability,” Atherosclerosis, vol. 212, no. 1, pp. 252–259, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. T. Chen, Z. Liu, M. Ouellet, F. Calon, and R. P. Bazinet, “Rapid β-oxidation of eicosapentaenoic acid in mouse brain: an in situ study,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 80, no. 2-3, pp. 157–163, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. C. T. Chen, A. F. Domenichiello, M.-O. Trépanier, Z. Liu, M. Masoodi, and R. P. Bazinet, “The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms,” Journal of Lipid Research, vol. 54, no. 9, pp. 2410–2422, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Freund Levi, I. Vedin, T. Cederholm et al., “Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study,” Journal of Internal Medicine, vol. 275, no. 4, pp. 428–436, 2014. View at Publisher · View at Google Scholar · View at Scopus