B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma

Table 4

Univariate and multivariate analyses of overall survival in OS patients.

Factors		Univariate			Multivariate
	Hazard ratio	95% CI		Hazard ratio	95% CI
Age, years (≤20/>20)	1.017	(0.954–1.057)	0.479	1.177	(0.671–1.571)	0.759
Gender (male/female)	1.134	(0.718–2.271)	0.379	1.537	(0.519–1.871)	0.442
Tumor stage (I, II/III)	6.771	(2.177–13.079)	<0.001	6.147	(2.274–11.34)	<0.001
Distant metastasis (yes/no)	2.977	(1.374–5.127)	0.002	1.871	(0.757–2.622)	0.179
Differentiation status (high/low)	1.297	(0.674–2.774)	0.057	1.087	(0.633–1.997)	0.217
B7-H4 expression (high/low)	5.257	(2.224–9.274)	<0.001	3.147	(1.32–7.377)	0.004
sB7-H4 levels (high/low)^*	4.371	(2.971–8.374)	0.001	2.022	(1.547–4.607)	0.041

^*92.28 ng/mL as the cutoff value to divide OS patients into groups with high (n = 36) and low (n = 50) sB7-H4 levels.