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BioMed Research International
Volume 2015, Article ID 156584, 11 pages
http://dx.doi.org/10.1155/2015/156584
Research Article

High Intensity Interval Training Favourably Affects Angiotensinogen mRNA Expression and Markers of Cardiorenal Health in a Rat Model of Early-Stage Chronic Kidney Disease

1Clinical Biochemistry Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia
2Human Exercise and Training Laboratory, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4702, Australia

Received 29 January 2015; Accepted 3 April 2015

Academic Editor: Macaulay Onuigbo

Copyright © 2015 Patrick S. Tucker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The majority of CKD-related complications stem from cardiovascular pathologies such as hypertension. To help reduce cardiovascular complications, aerobic exercise is often prescribed. Emerging evidence suggests high intensity interval training (HIIT) may be more beneficial than traditional aerobic exercise. However, appraisals of varying forms of aerobic exercise, along with descriptions of mechanisms responsible for health-related improvements, are lacking. This study examined the effects of 8 weeks of HIIT (85% VO2max), versus low intensity aerobic exercise (LIT; 45–50% VO2max) and sedentary behaviour (SED), in an animal model of early-stage CKD. Tissue-specific mRNA expression of RAAS-related genes and CKD-related clinical markers were examined. Compared to SED, HIIT resulted in increased plasma albumin (), reduced remnant kidney weight (), and reduced kidney weight-body weight ratios (). Compared to LIT, HIIT resulted in reduced Agt mRNA expression (), reduced plasma LDL (), triglycerides (), and total cholesterol (), increased plasma albumin (), reduced remnant kidney weight (), and reduced kidney weight-body weight ratios (). These results suggest HIIT is a more potent regulator of several markers that describe and influence health in CKD.