Research Article

Retrobulbar Hemodynamics and Visual Field Progression in Normal Tension Glaucoma: A Long-Term Follow-Up Study

Table 3

Compilation of studies focusing on correlations between CDI parameters and glaucoma progression.

StudyStudy designPatientsMethodsFollow-upSignificant findings related to visual field progression

Schumann et al. [17]RetrospectivePOAG () with progressive visual field defectsVFI mean defect over time50.1 ± 19.4 monthsMean blood flow velocities in the CRA, PSV, and RI in the OA

Gherghel et al. [18]RetrospectivePOAG ( with progressive visual field defects, matched patients with stable disease)Deepening of existing scotoma, expansion of existing scotoma, and fresh scotoma5.3 ± 2.2 yearsEDV in the CRA

Martínez and Sánchez [19]Prospective POAG (, 23 patients with progressive visual field defects)Deepening of existing scotoma, expansion of existing scotoma, and fresh scotoma36 monthsRI in the OA and SPCAs

Satilmis et al. [20]RetrospectivePOAG ( with progressive visual field defects)Deepening of existing scotoma, expansion of existing scotoma, fresh scotoma, and VFI mean defect over time4.3 ± 1.6 yearsEDV in the CRA

Galassi et al. [21]RetrospectivePOAG (, 18 with progressive visual field defects)Progressive visual field defect recorded in at least 3 consecutive examinationsUp to 7 yearsEDV and RI in the OA

Calvo et al. [22]ProspectiveGlaucoma suspects (, 36 with progressive disease)Color coded Moorfields Regression Analysis (MRA) in confocal laser scanning system48 monthsRI > 0.75 in the CRA

Zeitz et al. [23]ProspectiveGlaucoma (, 12 with progressive visual field defects)Increase in the cup-disc ratio of the optic disc and increase in MD 295 ± 18 daysPSV and EDV in the PCAs

Jimenez-Aragon et al. [24]ProspectivePOAG (, 12 with progressive visual field defects)Color coded Moorfields Regression Analysis (MRA) in confocal laser scanning system5 yearsRI in the OA and CRA

Kuerten et al. [25]RetrospectiveNTG ()VFI progression per year7.6 ± 4.1 yearsPSV of the CRA, RI of NPCA

NTG: normal tension glaucoma.
POAG: primary open-angle glaucoma.
VFI: Visual Field Index.
PSV: peak systolic velocity.
EDV: end-diastolic velocity.
RI: resistive index.
OA: ophthalmic artery.
CRA: central retinal artery.
NPCA: nasal posterior ciliary artery.
SPCA: small posterior ciliary artery.