An In Vivo Study of Low-Dose Intra-Articular Tranexamic Acid Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety
Table 4
value of coagulation and fibrinolytic markers between each groups.
value between groups
Preop.
2 hours
C.R.
24 hours
3 days
14 days
Platelet count
0.97
0.77
0.69
0.52
0.68
0.92
Prothrombin time
0.96
0.92
0.83
0.86
0.12
0.62
Partial thromboplastin time
0.53
0.62
0.66
0.89
0.13
0.90
Thrombin time
0.60
0.99
0.75
0.64
0.47
0.91
INR
0.95
0.95
0.30
0.95
0.12
0.66
D-dimer
0.37
0.21
0.64
0.53
0.62
Fibrinogen level
0.21
0.28
0.13
0.38
1.00
Plasmin inhibitor
0.78
0.42
0.71
0.38
0.71
NA
Plasminogen
0.75
0.11
0.41
0.27
0.61
NA
Plasminogen activator inhibitor
0.20
0.06
NA
Tissue plasminogen activator
0.23
0.08
0.09
NA
Preop.: preoperative, C.R.; clamp release, and INR; international normalized ratio. ; Significant difference among groups with , NA; not available.
