HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases

Table 2

Differences between siderosis and biochemical iron markers.

Liver tissue analysis; (Perls stain)	HFE-HH = 10	Non-HFE-HH iron elevation = 59
Siderosis grade
0	0	15
1	0	13
2	1	10
3	5	8
4	4	11
Serum iron indices	= 16	= 86	value
TS, %	91.02 ± 11.26	75.56 ± 17.59	0.001
Serum iron, mg/dL	212.65 ± 30.82	180.13 ± 48.16	0.001
Serum ferritin, μg/L	2676.75 ± 1928.87	1366.85 ± 945.88	0.012
Transferrin, mg/dL	192.73 ± 27.96	203.37 ± 57.47	0.830
Total iron binding capacity	229.46 ± 29.65	252.81 ± 78.26	0.975

HFE-HH: HFE hereditary hemochromatosis.
Non-HFE-HH iron elevation: patients with iron elevation not related to HFE-HH genotypes.
Results are expressed as mean ± SD.
Results present a comparison of the biochemical profiles of both groups after excluding six probable non-HFE HH from the analysis.