Switching the Sphingolipid Rheostat in the Treatment of Diabetes and Cancer Comorbidity from a Problem to an Advantage

Table 1

Comparative selectivity of the S1P modulators (adapted from [88]).

	S1P1	S1P2	S1P3	S1P4	S1P5
FTY720	++++	−	+	++	+++
CS-0777	+++	−	+	−	++
Ponesimod	+++	−	+	−	++
RPC0163	++++	+/−	+/−	+/−	++
ONO-4641	++	−	−	+	++
Siponimod	++	−	−	+	++
GSK2018682	++	−	−	−	+
KRP-203	+++	−	−	++	−
JTE-013	−	+++	−	−	−

+ indicates comparative selectivity of S1P modulators binding to individual receptors.