The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model

Table 2

The effects of oxytocin on plasma MDA, GSH, and TNF- levels in all groups.

	Normal control	Cisplatin + saline	Cisplatin + 80 μg/kg oxytocin	Cisplatin + 160 μg/kg oxytocin
MDA (nM)	62.5 ± 6.08	128.6 ± 9.09	104.4 ± 8.11^#	88.2 ± 5.5^##
GSH (μM)	19.4 ± 3.6	7.78 ± 1.09	11.2 ± 1.9^##	14.8 ± 1.6^##
TNF- (pg/mL)	23.2 ± 2.6	73.8 ± 7.7	43.5 ± 7.9^#	31.6 ± 5.8^##

Results were presented as mean ± SEM. < 0.001, different from normal and cisplatin + saline groups; < 0.05 and < 0.01 different from cisplatin + saline groups.