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BioMed Research International
Volume 2015, Article ID 168089, 9 pages
http://dx.doi.org/10.1155/2015/168089
Research Article

Epithelial-Mesenchymal Transition in Keratocystic Odontogenic Tumor: Possible Role in Locally Aggressive Behavior

1State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, China
2Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
3Department of Prosthodontics, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China

Received 22 November 2014; Revised 27 February 2015; Accepted 27 February 2015

Academic Editor: Li Wu Zheng

Copyright © 2015 Wen-Qun Zhong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. D. R. Thompson, “World Health Organization classification of tumours: pathology and genetics of head and neck tumours,” Ear, Nose and Throat Journal, vol. 85, no. 2, p. 74, 2006. View at Google Scholar · View at Scopus
  2. J. P. Sleeman and J. P. Thiery, “SnapShot: the epithelial-mesenchymal transition,” Cell, vol. 145, no. 1, pp. 162–162.e1, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Friedl and S. Alexander, “Cancer invasion and the microenvironment: plasticity and reciprocity,” Cell, vol. 147, no. 5, pp. 992–1009, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Jia, W. Zhang, J.-Y. Liu et al., “Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma,” PLoS ONE, vol. 7, no. 12, Article ID e51549, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Tsuji, S. Ibaragi, and G.-F. Hu, “Epithelial-mesenchymal transition and cell cooperativity in metastasis,” Cancer Research, vol. 69, no. 18, pp. 7135–7139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Cheng, Y. Zhou, W. Jiang et al., “Significance of E-cadherin, beta-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma,” Human Pathology, vol. 43, no. 8, pp. 1213–1220, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. J. E. Kwon, W.-H. Jung, and J. S. Koo, “Molecules involved in epithelial-mesenchymal transition and epithelial-stromal interaction in phyllodes tumors: implications for histologic grade and prognosis,” Tumor Biology, vol. 33, no. 3, pp. 787–798, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Xiong, K. Mrozik, S. Gronthos, and P. M. Bartold, “Epithelial cell rests of malassez contain unique stem cell populations capable of undergoing epithelial-mesenchymal transition,” Stem Cells and Development, vol. 21, no. 11, pp. 2012–2025, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. W.-Q. Zhong, G. Chen, W. Zhang et al., “Down-regulation of connexin43 and connexin32 in keratocystic odontogenic tumours: potential association with clinical features,” Histopathology, 2015. View at Publisher · View at Google Scholar
  10. G. Chen, W. Zhang, Y.-P. Li et al., “Hypoxia-induced autophagy in endothelial cells: a double-edged sword in the progression of infantile haemangioma?” Cardiovascular Research, vol. 98, no. 3, pp. 437–448, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. K.-F. He, L. Zhang, C.-F. Huang et al., “CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma,” BioMed Research International, vol. 2014, Article ID 838632, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Polyak and R. A. Weinberg, “Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits,” Nature Reviews Cancer, vol. 9, no. 4, pp. 265–273, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. P. Thiery, H. Acloque, R. Y. J. Huang, and M. A. Nieto, “Epithelial-mesenchymal transitions in development and disease,” Cell, vol. 139, no. 5, pp. 871–890, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. P. P. de Andrade Santos, A. R. L. de Aquino, A. Oliveira Barreto, R. de Almeida Freitas, H. C. Galvão, and L. B. de Souza, “Immunohistochemical expression of nuclear factor κb, matrix metalloproteinase 9, and endoglin (CD105) in odontogenic keratocysts, dentigerous cysts, and radicular cysts,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 112, no. 4, pp. 476–483, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. H. M. Amm, M. D. Casimir, D. B. Clark, P. Sohn, and M. MacDougall, “Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells,” Connective Tissue Research, vol. 55, supplement 1, pp. 97–101, 2014. View at Publisher · View at Google Scholar
  16. M. Concepción Garrido, L. Requena, H. Kutzner, P. Ortiz, B. Pérez-Gómez, and J.-L. Rodriguez-Peralto, “Desmoplastic melanoma: expression of epithelial-mesenchymal transition-related proteins,” The American Journal of Dermatopathology, vol. 36, no. 3, pp. 238–242, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Vargová, M. Pytliak, and V. Mechírová, “Matrix metalloproteinases,” EXS, vol. 103, pp. 1–33, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. C. C. Lynch, “Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis,” Bone, vol. 48, no. 1, pp. 44–53, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Quan, M. Elhousiny, N. W. Johnson, and J. Gao, “Transforming growth factor-β1 treatment of oral cancer induces epithelial-mesenchymal transition and promotes bone invasion via enhanced activity of osteoclasts,” Clinical and Experimental Metastasis, vol. 30, no. 5, pp. 659–670, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Kubota, T. Ninomiya, S. Oka, Y. Takenoshita, and K. Shirasuna, “Interleukin-1α-dependent regulation of matrix metalloproteinase-9 (MMP-9) secretion and activation in the epithelial cells of odontogenic jaw cysts,” Journal of Dental Research, vol. 79, no. 6, pp. 1423–1430, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. A. L. R. Ribeiro, R. M. Nobre, S. M. Alves-Junior et al., “Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and growth factors regulate the aggressiveness and proliferative activity of keratocystic odontogenic tumors,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 114, no. 4, pp. 487–496, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Onoue, D. Uchida, N. M. Begum, Y. Tomizuka, H. Yoshida, and M. Sato, “Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells,” International Journal of Oncology, vol. 29, no. 5, pp. 1133–1138, 2006. View at Google Scholar · View at Scopus
  23. Y. Shi, H. Wu, M. Zhang, L. Ding, F. Meng, and X. Fan, “Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma,” Diagnostic Pathology, vol. 8, article 89, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. J. N. Dos Santos, G. Q. V. Oliveira, C. A. S. Gurgel et al., “Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors,” Journal of Molecular Histology, vol. 40, no. 4, pp. 269–275, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Stoll, C. Stollenwerk, D. Riediger, C. Mittermayer, and J. Alfer, “Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts,” Journal of Oral Pathology and Medicine, vol. 34, no. 9, pp. 558–564, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Acloque, M. S. Adams, K. Fishwick, M. Bronner-Fraser, and M. A. Nieto, “Epithelial-mesenchymal transitions:the importance of changing cell state in development and disease,” The Journal of Clinical Investigation, vol. 119, no. 6, pp. 1438–1449, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Kang and J. Massagué, “Epithelial-mesenchymal transitions: twist in development and metastasis,” Cell, vol. 118, no. 3, pp. 277–279, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. M. K. Asiedu, J. N. Ingle, M. D. Behrens, D. C. Radisky, and K. L. Knutson, “TGFβ/TNFα-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype,” Cancer Research, vol. 71, no. 13, pp. 4707–4719, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Qiao, N. W. Johnson, and J. Gao, “Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions,” International Journal of Oncology, vol. 37, no. 3, pp. 663–668, 2010. View at Google Scholar · View at Scopus