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BioMed Research International
Volume 2015, Article ID 168358, 14 pages
Research Article

Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAs/isomiRs Levels

1Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2Shandong Provincial Key Laboratory of Functional Macromolecular Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China

Received 12 June 2014; Revised 27 September 2014; Accepted 29 September 2014

Academic Editor: Yuedong Yang

Copyright © 2015 Li Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: showed that examples of nucleotide divergence between different miRNAs, including 5p-miRNA and 3p-miRNA, and miR-#-5p and miR-#-3p.

Figure S2-S4: showed box plots of miRNAs between different samples using standard deviation (SD), and Figure S5 presented examples of functional analysis.

Table S1: listed selected small RNA sequencing datasets from the TCGA database.

Table S2: showed the common miRNAs in the ten animal species.

Table S3: presented Wilcoxon signed-rank test of miR-#-5p and miR-#-3p.

Table S4: showed spearman correlation coefficient between homologous miRNAs.

Table S5: presented the free energies of some pre-miRNAs.

Table S6-S8: showed isomiR expression distributions of let-7a-5p, homologous miR-30a and miR-30e, miR-10b and miR-21 across all samples.

  1. Supplementary Material