Figure 1: Mechanism of drug induced hepatic steatosis/steatohepatitis. ATP-citrate lyase (ACL), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), long-chain fatty acyl elongase (LCE), stearoyl-CoA desaturase (SCD), sterol regulatory element-binding protein-1c (SREBP-1c), apolipoprotein B (ApoB), triglyceride transfer protein (MTP), very-low-density lipoprotein (VLDL), carnitine-palmitoyl-transferase I (CPT I), tricarboxylic acid cycle (TCA cycle), electron transport chain (ETC), reactive oxygen species (ROS), nucleoside reverse transcriptase inhibitors (NRTI), valproic acid (VPA), methotrexate (MTX), 5-fluorouracil (5-FU), and irinotecan (IRI).