Review Article

Development of Monoclonal Antibodies in China: Overview and Prospects

Table 4

Chinese leading mAbs R&D institutions.

NumberR&D institutionsOngoingProductsRemarks

1Academy of Military Medical ScienceGene cloning, humanized constructionAnti-tetanus antibodyAt present the only state-level antibody pharmaceutical engineering research institute in China

2Institute of Genetics and Developmental Biology, CASHigh expression and platform construction of phage antibody library technology, group sequencing to gene mapping and cloningAntiencephalitis B mAbN/A

3Cancer Institute and Hospital, Chinese Academy of Medical SciencesHumanized engineering and high expression, proteomic study of “gene-environment interactions” of esophagus cancerN/ASet the tumor medical research and teaching as a whole

4Institute of Medical Biotechnology Academy of Medical Sciences and Peking Union Medical CollegeMolecular miniaturization and high efficient, genetic engineering fusion protein based on Lidamycin and Fab’, Fab, VH, VLN/AN/A

5Shanghai Institutes for Biological Sciences, CASThe introduction and imitation of antibody, preparation of antibody, and proteome research platform supportN/AShanghai R&D Public Service Platform

6Institute Pasteur of Shanghai CASGene cloning, tumor immune cure, and gene therapy which based on DCN/AN/A

7Southern Medical University (former the First Military Medical University)Tumor targeted biological treatment, applied gene chipN/AThe first biotechnology experimental base in Guangdong province

8Cell Engineering Research Center, the Fourth Military Medical University Screening techniques of phage antibody libraries and optimization platform establishmentIodine (131I) antitumor necrosis therapy injectionNational cell engineering Intermediate test base, antibodies to large-scale preparation technology platform

Notes: each row of the table shows the current status of R&D in China: “Ongoing” represents research activities of the institutions focusing on mAbs. “CAS” is Chinese Academy of Sciences. “DC” is dendritic cell.
Source: author’s analysis and online source.