Research Article
Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension
Table 1
Demographic data patients with pulmonary artery hypertension and healthy controls.
| | | Non-PAH () | COPD-PH () | IPAH () | value |
| | Age, yrs | 51.30 ± 11.71 (64–38) | 58.9 ± 12.96 (75–39) | 45.4 ± 16.16 (78–18) | 0.16 | | Sex (male/female) | 22/5 | 16/4 | 6/14 | 0.000 | | Height, cm | 161.94 ± 6.84 (182–152) | 160.63 ± 7.22 (169.5–144) | 158.93 ± 7.53 (176–147) | 0.366 | | Weight, kg | 66.65 ± 12.31 (86.5–49.5) | 67.28 ± 12.50 (94–46) | 63.51 ± 13.43 (98–46) | 0.578 | | BMI, kg/m2 | 25.45 ± 3.91 (33.76–18.29) | 16.16 ± 5.10 (38.58–17.10) | 25.15 ± 5.64 (42.7–18.36) | 0.791 | | History of DM | 5 (18.5%) | 5 (25.0%) | 0 (0) | 0.68 | | History of HTN | 8 (29.6%) | 10 (45.5%) | 4 (18.2%) | 0.117 | | PAP peak (mmHg) | 17.69 ± 4.48 (8–25.8) | 46.76 ± 12.74 (35–72.6) | 96.37 ± 30.76 (47.30–169) | 0.000 | | PAP mean (mmHg) | 12.36 ± 2.89 (6.3–18.80) | 31.14 ± 7.93 (23.4–48.4) | 57.79 ± 14.87 (29.60–84.5) | 0.000 | | SBP, mmHg | 133.35 ± 16.01 (170–104) | 132.80 ± 22.24 (176–96) | 113.20 ± 23.10 (175–86) | 0.002 | | DBP, mmHg | 79.77 ± 9.60 (101–60) | 81.80 ± 16.87 (119–62) | 77.80 ± 16.87 (128–54) | 0.683 | | TC, mg/dL | 176.88 ± 35.35 (236–92) | 183.35 ± 44.46 (281–105) | 146.25 ± 33.39 (188–103) | 0.078 | | HDL_C, mg/dL | 41.6 ± 9.31 (59–29) | 48.8 ± 38.5 (166–6) | 52.4 ± 14.84 (66–33) | 0.753 | | TG, mg/dL | 142.88 ± 69.20 (373–53) | 127.50 ± 94.72 (458–23) | 79.88 ± 33.28 (148–38) | 0.139 | | Creatinine, mg/dL | 1.08 ± 0.27 (2–0.7) | 1.44 ± 0.75 (4.4–0.8) | 0.88 ± 1.6 (1.2–0.6) | 0.515 | | AC_sugar, mg/dL | 108.23 ± 26.36 (177–79) | 110.50 ± 42.04 (235–49) | 108.75 ± 34.78 (189–83) | 0.980 | | Caveolin-1 pg/mL | 173.57 ± 135.18 (47.22–409.44) | 163.04 ± 146.59 (56.61–425.54) | 33.81 ± 36.3 (18–235) | 0.029 | | hsCRP mg/dL | 0.18 ± 0.23 (0.1–0.95) | 1.02 ± 1.30 (0.13–4.38) | 0.37 ± 0.62 (0.03–2.75) | 0.007 | | NT-proBNP pg/mL | 59.83 ± 64.84 (4.0–336) | 1426 ± 1231 (140–2790) | 933.6 ± 891.3 (107–2120) | 0.004 |
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PAH: pulmonary artery hypertension, COPD-PH: chronic obstructive pulmonary disease with pulmonary hypertension, IPAH: idiopathic PAH, PAP: pulmonary artery pressure, SBP: systolic blood pressure, DBP: diastolic blood pressure, hsCRP: high-sensitivity C-reactive protein, and NT-proBNP: N-terminal of the prohormone brain natriuretic peptide.
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