Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balb/c Mice

Figure 2

Immunelocalization of glucose transporters in placenta of female mice. The photomicrographs represent immunelocalization of GLUT transporters in placenta from nonexposed females. Samples were counterstained with hematoxylin after an immunohistochemical procedure. (a), (c), and (e) show a positive signal for GLUT1, 3, and 4, respectively, (arrows) in mouse placenta. GLUT1 was identified on both sides of the maternal-fetal interface while GLUT3 was localized mainly in the fetal endothelium. GLUT4 was detected in both syncytiotrophoblast and stromal cells. Positive controls were mounted in rat tissues: (b) heart for GLUT1; (d) testis for GLUT3; and (f) heart for GLUT4. The signal for GLUT1 and GLUT4 was localized on myocytes sarcoplasm and GLUT3 in cytosol of Sertoli cells. ME: maternal erythrocyte; FE: fetal erythrocyte. Magnification 60x.

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