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BioMed Research International
Volume 2015, Article ID 179756, 7 pages
http://dx.doi.org/10.1155/2015/179756
Research Article

Effect of Leukocyte-Rich and Platelet-Rich Plasma on Healing of a Horizontal Medial Meniscus Tear in a Rabbit Model

1Department of Orthopaedic Surgery, Korea University Anam Hospital, Korea University College of Medicine & Medical School, Seoul 136-705, Republic of Korea
2Korea University College of Medicine & Medical School, Seoul 136-705, Republic of Korea
3Department of Orthopaedic Surgery, Korea University Ansan Hospital, Korea University College of Medicine & Medical School, Ansan 425-707, Republic of Korea
4Department of Orthopaedic Surgery, Korea University Guro Hospital, Korea University College of Medicine & Medical School, Seoul 152-703, Republic of Korea

Received 1 December 2014; Revised 24 May 2015; Accepted 25 May 2015

Academic Editor: Raymond P. Goodrich

Copyright © 2015 Kyun Ho Shin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There are limited reports on the effect of platelet-rich plasma (PRP) on meniscus healing. The purpose of this study was to investigate the effect of leukocyte-rich PRP (L-PRP) on potential healing of the horizontal medial meniscus tears in a rabbit model. A horizontal medial meniscus tear was created in both knees of nine skeletally mature adult rabbits. Left or right knees were randomly assigned to a L-PRP group, or a control group. 0.5 mL of L-PRP from 10 mL of each rabbit’s whole blood was prepared and injected into the horizontal tears in a L-PRP group. None was applied to the horizontal tears in a control group. The histological assessment of meniscus healing was performed at two, four, and six weeks after surgery. We found that there were no significant differences of quantitative histologic scoring between two groups at 2, 4, and 6 weeks after surgery (). This study failed to show the positive effect of single injection of L-PRP on enhancing healing of the horizontal medial meniscus tears in a rabbit model. Single injection of L-PRP into horizontal meniscus tears may not effectively enhance healing of horizontal medial meniscus tears.