Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 179867, 7 pages
http://dx.doi.org/10.1155/2015/179867
Research Article

The Effect of CYP, GST, and SULT Polymorphisms and Their Interaction with Smoking on the Risk of Hepatocellular Carcinoma

1Institute of Public Health, Section of Hygiene, Department of Public Health, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
2IRCCS San Raffaele Pisana, Via della Pisana 235, 00163 Rome, Italy
3Institute of Internal Medicine, Gemelli Hospital, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
4Internal Medicine and Gastroenterology Unit, Complesso Integrato Columbus, Via Giuseppe Moscati 31-33, 00168 Rome, Italy
5University Clinical-Hospital Center “Dr Dragisa Misovic-Dedinje”, Milana Tepica 1, 11000 Belgrade, Serbia
6Department of Epidemiology, IRCCS Istituto di Ricerche Farmacologiche “Mario Negri”, Via La Masa 19, 20156 Milan, Italy
7Faculty of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia
8Internal Medicine and Gastroenterology Division, Gemelli Hospital, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
9Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, Italy

Received 16 April 2014; Revised 19 June 2014; Accepted 19 June 2014

Academic Editor: Paolo Boffetta

Copyright © 2015 Stefania Boccia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. International Agency on Research of Cancer, 2012, http://globocan.iarc.fr/Default.aspx.
  2. M. op den Winkel, D. Nagel, J. Sappl et al., “Prognosis of patients with hepatocellular carcinoma. validation and ranking of established staging-systems in a large Western HCC-Cohort,” PLoS ONE, vol. 7, no. 10, Article ID e45066, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Chuang, C. L. Vecchia, and P. Boffetta, “Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection,” Cancer Letters, vol. 286, no. 1, pp. 9–14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Franceschi, M. Montella, J. Polesel et al., “Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 4, pp. 683–689, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Turati, R. Talamini, C. Pelucchi et al., “Metabolic syndrome and hepatocellular carcinoma risk,” British Journal of Cancer, vol. 108, no. 1, pp. 222–228, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Bravi, C. Bosetti, A. Tavani, S. Gallus, and C. La Vecchia, “Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis,” Clinical Gastroenterology and Hepatology, vol. 11, no. 11, pp. 1413–1421, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Gao, Q. Jiang, X. Zhou et al., “HBV infection and familial aggregation of liver cancer: an analysis of case-control family study,” Cancer Causes and Control, vol. 15, no. 8, pp. 845–850, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Jin, W. J. Xiong, J. C. Jing, Z. Feng, L. S. Qu, and X. Z. Shen, “Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review,” Journal of Cancer Research and Clinical Oncology, vol. 137, no. 7, pp. 1095–1104, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J. A. Hasler, “Pharmacogenetics of cytochromes P450,” Molecular Aspects of Medicine, vol. 20, no. 1-2, pp. 12–137, 1999. View at Google Scholar · View at Scopus
  10. J. D. Hayes and D. J. Pulford, “The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance,” Critical Reviews in Biochemistry and Molecular Biology, vol. 30, no. 6, pp. 445–600, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Gamage, A. Barnett, N. Hempel et al., “Human sulfotransferases and their role in chemical metabolism,” Toxicological Sciences, vol. 90, no. 1, pp. 5–22, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Song, J. Yi, X. Shen, and Y. Cai, “Genetic polymorphisms of glutathione S- transferase genes GSTM1, GSTT1 and risk of hepatocellular carcinoma,” PLoS ONE, vol. 7, no. 11, Article ID e48924, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Yu, L. Sun, Y. Jiang, B. Lu, D. Sun, and L. Zhu, “Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies,” Molecular Biology Reports, vol. 39, no. 6, pp. 6641–6646, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Bruix and M. Sherman, “Management of Hepatocellular carcinoma,” Hepatology, vol. 42, no. 5, pp. 1208–1236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Arand, R. Mühlbauer, J. Hengstler et al., “A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms,” Analytical Biochemistry, vol. 236, no. 1, pp. 184–186, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. M. W. Coughtrie, R. A. Gilissen, B. Shek et al., “Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations,” Biochemical Journal, vol. 337, no. 1, pp. 45–49, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. N. E. Breslow and N. E. Day, Statistical Methods in Cancer Research, Vol. 1. The Analysis of Case-Control Studies, IARC, Lyon, France, 1980.
  18. K. F. Hirji, C. R. Mehta, and N. R. Patel, “Exact inference for matched case-control studies,” Biometrics. Journal of the Biometric Society, vol. 44, no. 3, pp. 803–814, 1988. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus
  19. K. J. Rothman, “Measuring interactions,” in Epidemiology: An Introduction, K. J. Rothman, Ed., pp. 168–190, Oxford University Press, New York, NY, USA, 2002. View at Google Scholar
  20. T. Andersson, L. Alfredsson, H. Källberg, S. Zdravkovic, and A. Ahlbom, “Calculating measures of biological interaction,” European Journal of Epidemiology, vol. 20, no. 7, pp. 575–579, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Little, J. P. T. Higgins, J. P. A. Ioannidis et al., “Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement,” Italian Journal of Public Health, vol. 6, no. 3, pp. 238–255, 2009. View at Google Scholar · View at Scopus
  22. F. P. Guengerich, D.-H. Kim, and M. Iwasaki, “Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects,” Chemical Research in Toxicology, vol. 4, no. 2, pp. 168–179, 1991. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Albano, P. Clot, M. Morimoto, A. Tomasi, M. Ingelman-Sundberg, and S. W. French, “Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol,” Hepatology, vol. 23, no. 1, pp. 155–163, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. S.-M. Wang, A.-P. Zhu, D. Li, Z. Wang, P. Zhang, and G. Zhang, “Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland chinese kazakh, uygur and han populations,” Journal of Human Genetics, vol. 54, no. 6, pp. 372–375, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M.-W. Yu, A. Gladek-Yarborough, S. Chiamprasert et al., “Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma,” Gastroenterology, vol. 109, no. 4, pp. 1266–1273, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. N. A. Wong, F. Rae, K. J. Simpson, G. D. Murray, and D. J. Harrison, “Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis,” Journal of Clinical Pathology—Molecular Pathology, vol. 53, no. 2, pp. 88–93, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Munaka, K. Kohshi, T. Kawamoto et al., “Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma,” Journal of Cancer Research and Clinical Oncology, vol. 129, no. 6, pp. 355–360, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Koide, T. Ohno, X. E. Huang et al., “HBV/HCV infection, alcohol, tobacco and genetic polymorphisms for hepatocellular carcinoma in Nagoya, Japan,” Asian Pacific Journal of Cancer Prevention, vol. 1, no. 3, pp. 237–243, 2000. View at Google Scholar · View at Scopus
  29. X. P. Ye, T. Peng, T. W. Liu et al., “The effect of interaction between alcohol drinking and polymorphisms of cytochrome P450 2E1 on the susceptibility of Hepatocellular carcinoma in Guangxi region,” Journal of Guangxi Medical University, vol. 25, no. 4, pp. 493–495, 2008 (Chinese). View at Google Scholar
  30. J. M. Ladero, J. A. Agúndez, A. Rodríguez-Lescure, M. Diaz-Rubio, and J. Benítez, “RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma,” Gut, vol. 39, no. 2, pp. 330–333, 1996. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Imaizumi, Y. Higaki, M. Hara et al., “Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population,” Carcinogenesis, vol. 30, no. 10, pp. 1729–1734, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. N. A. Wong, F. Rae, K. J. Simpson, G. D. Murray, and D. J. Harrison, “Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis,” Molecular Pathology, vol. 53, no. 2, pp. 88–93, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Z. Yu, X. E. Huang, T. Koide et al., “Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China,” Japanese Journal of Cancer Research, vol. 93, no. 12, pp. 1287–1292, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. H. S. Lee, J. H. Yoon, S. Kamimura et al., “Lack of association of cytochrome P450 2E1 genetic polymorphisms with the risk of human hepatocellular carcinoma,” International Journal of Cancer, vol. 71, no. 5, pp. 737–740, 1997. View at Google Scholar
  35. L. Silvestri, L. Sonzogni, A. De Silvestri et al., “CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer,” International Journal of Cancer, vol. 104, no. 3, pp. 310–317, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Liu, H. Wang, C. Pan, J. Shen, and Y. Liang, “CYP2E1 PstI/RsaI polymorphism and interaction with alcohol consumption in hepatocellular carcinoma susceptibility: evidence from 1,661 cases and 2,317 controls,” Tumour Biology, vol. 33, no. 4, pp. 979–984, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Trichopoulos, C. Bamia, P. Lagiou et al., “Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study,” Journal of the National Cancer Institute, vol. 103, no. 22, pp. 1686–1695, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Nowell, C. B. Ambrosone, S. Ozawa et al., “Relationship of phenol sulfotransferase activity (SULT1A1) genotype to sulfotransferase phenotype in platelet cytosol,” Pharmacogenetics, vol. 10, no. 9, pp. 789–797, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Juárez-Cedillo, M. Vallejo, J. M. Fragoso et al., “The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism,” European Journal of Cancer, vol. 43, no. 10, pp. 1590–1595, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Shin, D. Kang, J. Y. Choi et al., “Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women,” Experimental and Molecular Medicine, vol. 39, no. 3, pp. 361–366, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Zhan, Q. Wang, Q. Qian, S. Wei, and L. Yu, “CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: an updated meta-analysis and review,” Journal of Experimental and Clinical Cancer Research, vol. 30, no. 1, article 99, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Covolo, U. Gelatti, R. Talamini et al., “Alcohol dehydrogenase 3, glutathione S-transferase M1 and T1 polymorphisms, alcohol consumption and hepatocellular carcinoma (Italy),” Cancer Causes and Control, vol. 16, no. 7, pp. 831–838, 2005. View at Publisher · View at Google Scholar · View at Scopus