Early Fluid Resuscitation and High Volume Hemofiltration Decrease Septic Shock Progression in Swine
Table 2
Parameters during treatment according to groups.
Variable/ group
Upon successful resuscitation
1 h
2 h
3 h
4 h
5 h
6 h
CO (L/min)
Control
7.8 (7; 8.3)
6.7 (6.2; 7.1)
5.5 (4.5; 5.7)
4.5 (4.2; 5.1)
4.1 (3.9; 4.5)
3.8 (3.6; 4.0)
3.4 (3.1; 3.6)
CRRT
7.3 (7.2; 7.7)
6.4 (5.7; 6.6)
4.9 (4.6; 5.3)
4.3 (4.1; 4.4)
4.0 (3.5; 4.4)
3.6 (3.2; 3.7)
3.0 (3; 3.1)
HVHF
7.6 (7.2; 8.3)
6.4 (6.1; 7.1)
5.4 (4.9; 6.1)
5.0 (4.8; 5.2)
4.8 (4.7; 4.9)
4.8 (4.7; 4.9)
4.6 (4.3; 4.7)
0.612
0.407
0.278
0.110
0.010
0.002
0.002
HR (bpm)
Control
125 (119; 127)
128 (124; 131)
129 (121; 134)
131 (121; 133)
121 (119; 128)
119 (117; 129)
123 (122; 126)
CRRT
121 (119; 124)
128 (118; 132)
131 (122; 135)
127 (120; 132)
123 (120; 129)
131 (128; 133)
120 (119; 122)
HVHF
124 (120; 127)
130 (120; 134)
123 (120; 131)
122 (118; 124)
125 (122; 127)
121 (119; 134)
120 (118; 128)
0.494
0.787
0.579
0.224
0.659
0.132
0.202
dPmax (mmHg/s)
Control
533 (481; 555)
485 (446; 517)
432 (410; 476)
414 (407; 464)
457 (417; 462)
399 (383; 418)
402 (398; 412)
CRRT
468 (443; 511)
478 (443; 510)
440 (409; 466)
437 (412; 458)
427 (397; 450)
412 (398; 423)
411 (400; 414)
HVHF
500 (490; 540)
505 (480; 525)
459 (443; 476)
456 (449; 481)
479 (447; 512)
505 (485; 516)
546 (531; 565)
0.103
0.404
0.345
0.211
0.035
0.003
0.004
Infusion volume (mL)
Control
107.0 (97.0; 112.5)
116.5 (106.3; 124.8)
112.0 (108.5; 123.0)
135.0 (103.5; 138.5)
108.0 (97.5; 134.0)
113.0 (98.5; 128.0)
CRRT
88.0 (79.3; 102.5)
90.0 (85; 107.5)
94.5 (82.5; 101.0)
105.0 (92.5; 123.3)
96.0 (93.0; 100.3)
117.5 (92.5; 130.8)
HVHF
87.0 (81.3; 95.8)
71.0 (45.3; 83.8)
76.0 (58.8; 88.3)
46.0 (25.8; 59.5)
58.0 (27; 68.5)
40.5 (33.5; 52.3)
0.041
0.003
0.003
0.002
0.003
0.004
Highest dose of norepinephrine (μg/min)
Control
0.4 (0; 0.8)
1.0 (0.9; 1.6)
2.0 (1.4; 2.0)
1.5 (1.5; 1.8)
1.5 (1.1; 1.6)
1.8 (1.4; 2.1)
1.8 (1.8; 2.0)
CRRT
0.5 (0.2; 0.6)
1.0 (0.9; 1.5)
1.3 (1.0; 1.8)
1.8 (1.4; 1.8)
1.5 (1.4; 1.6)
1.9 (1.5; 2.1)
1.9 (1.4; 2.6)
HVHF
0.5 (0.4; 0.8)
1.0 (0.9; 1.3)
1.8 (1.2; 1.8)
1.5 (1.4; 1.8)
1.1 (0.9; 1.3)
0.4 (0.2; 0.6)
0.5 (0.2; 0.8)
0.615
0.958
0.142
0.537
0.02
0.004
0.004
PO2 (mmHg)
Control
210 (197; 218)
193 (176; 208)
184 (174; 200)
175 (143; 193)
130 (127; 165)
135 (132; 155)
136 (128; 159)
CRRT
196 (194; 203)
193 (181; 205)
179 (174; 195)
178 (171; 187)
165 (151; 175)
155 (143; 162)
146 (136; 166)
HVHF
199 (194; 210)
208 (189; 209)
193 (184; 208)
191 (186; 195)
188 (182; 191)
190 (187; 194)
189 (184; 197)
0.194
0.306
0.204
0.144
0.002
0.002
0.004
PVPI
Control
1.5 (1.3; 2.3)
1.6 (1.6; 2.3)
1.8 (1.6; 2.5)
3.0 (2.9; 3.5)
3.8 (3.4; 4.1)
4.0 (3.9; 4.4)
4.6 (4.4; 4.8)
CRRT
1.9 (1.8; 1.9)
1.9 (1.8; 2.1)
2.0 (1.9; 2.0)
2.9 (2.2; 3.1)
3.1 (2.7; 3.5)
3.6 (3.5; 3.8)
4.0 (3.8; 4.2)
HVHF
2.0 (1.8; 2.2)
2.1 (1.7; 2.3)
2.1 (1.9; 2.6)
2.3 (2.1; 2.6)
2.4 (2.3; 2.6)
2.4 (2.3; 2.6)
2.4 (2.2; 2.8)
0.349
0.45
0.494
0.037
0.003
0.001
0.001
CRRT: continuous renal replacement therapy; HVHF: high volume hemofiltration; CO: cardiac output; HR: heart rate; dPmax: left ventricular contractility index, PVPI: pulmonary vascular permeability index; PO2: arterial oxygen pressure. between the CRRT and control groups, between the HVHF and control groups, between the CRRT and HVHF groups.
