Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 182107, 8 pages
http://dx.doi.org/10.1155/2015/182107
Review Article

Recent Advances in Genetic Technique of Microbial Report Cells and Their Applications in Cell Arrays

1Department of Bionano Technology, Gachon University, Gyeonggi 461-701, Republic of Korea
2Department of Chemical and Biomolecular Engineering (BK21+ Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea

Received 23 April 2015; Accepted 26 August 2015

Academic Editor: Yun-Peng Chao

Copyright © 2015 Do Hyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microbial cell arrays have attracted consistent attention for their ability to provide unique global data on target analytes at low cost, their capacity for readily detectable and robust cell growth in diverse environments, their high degree of convenience, and their capacity for multiplexing via incorporation of molecularly tailored reporter cells. To highlight recent progress in the field of microbial cell arrays, this review discusses research on genetic engineering of reporter cells, technologies for patterning live cells on solid surfaces, cellular immobilization in different polymers, and studies on their application in environmental monitoring, disease diagnostics, and other related fields. On the basis of these results, we discuss current challenges and future prospects for novel microbial cell arrays, which show promise for use as potent tools for unraveling complex biological processes.