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BioMed Research International
Volume 2015 (2015), Article ID 183074, 8 pages
http://dx.doi.org/10.1155/2015/183074
Research Article

Gender Differences in Cerebral Regional Homogeneity of Adult Healthy Volunteers: A Resting-State fMRI Study

1Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China
2Laboratory of Digital Medical Imaging, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China
3Institute of Computer Application of Chinese Medicine, Anhui Academy of Chinese Medicine, Anhui 230038, China
4Graduate School, Anhui University of Chinese Medicine, Anhui 230038, China
5Department of Electronic Science and Technology, University of Science & Technology of China, Anhui 230027, China
6Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
7School of Acupuncture & Osteology, Anhui University of Chinese Medicine, Anhui 230038, China
8Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China
9CAS Key Laboratory of Brain Function & Disease and School of Life Sciences, University of Science & Technology of China, Anhui 230027, China
10Center of Medical Physics and Technology, Hefei Institutes of Physical Science, CAS, Anhui 230031, China

Received 14 May 2014; Revised 7 September 2014; Accepted 30 September 2014

Academic Editor: Hengyi Rao

Copyright © 2015 Chunsheng Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. We sought to use the regional homogeneity (ReHo) approach as an index in the resting-state functional MRI to investigate the gender differences of spontaneous brain activity within cerebral cortex and resting-state networks (RSNs) in young adult healthy volunteers. Methods. One hundred and twelve healthy volunteers (56 males, 56 females) participated in the resting-state fMRI scan. The ReHo mappings in the cerebral cortex and twelve RSNs of the male and female groups were compared. Results. We found statistically significant gender differences in the primary visual network (PVN) (, with Bonferroni correction) and left attention network (LAtN), default mode network (DMN), sensorimotor network (SMN), executive network (EN), and dorsal medial prefrontal network (DMPFC) as well (, uncorrected). The male group showed higher ReHo in the left precuneus, while the female group showed higher ReHo in the right middle cingulate gyrus, fusiform gyrus, left inferior parietal lobule, precentral gyrus, supramarginal gyrus, and postcentral gyrus. Conclusions. Our results suggested that men and women had regional specific differences during the resting-state. The findings may improve our understanding of the gender differences in behavior and cognition from the perspective of resting-state brain function.