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BioMed Research International
Volume 2015, Article ID 183469, 14 pages
http://dx.doi.org/10.1155/2015/183469
Review Article

Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury

Department of Surgery, University of Florida, Gainesville, FL 32610, USA

Received 29 May 2015; Revised 10 November 2015; Accepted 11 November 2015

Academic Editor: Sung-Hoon Kim

Copyright © 2015 Kristina L. Go et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury.