Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer

Table 6

ROC curves of potential serum biomarker levels for differentiating the control group from the PRLC group.

Marker	Cutoff value	Sensitivity (%)	Specificity (%)	AUC	p value^*	95% CI^a
Prasterone sulfate	91.07	76.67	80.00	0.787	<0.001	0.670–0.905
Sphingosine	102.76	90.00	96.67	0.957	<0.001	0.894–1.019
Serine	113.21	83.33	73.33	0.774	<0.001	0.645–0.904
2,3,4-Trihydroxybutyric acid	45.87	86.67	83.33	0.880	<0.001	0.794–0.966

 ^*Asymptotic significance, null hypothesis: true area = 0.5.
^a95% confidence interval of the difference.