Beyond the Limits: Clinical Utility of Novel Cardiac Biomarkers

Table 2

Summary of original articles from the literature proving the significance of miRNA as cardiac biomarker.

Authors	Year	Study type	Number of patients	Statistical significance
Raitoharju et al. [32]	2011	Laboratory study	12 atherosclerotic plaques
Li et al. [31]	2011	Clinical study	104 patients with atherosclerosis obliterans	miR-21, miR-130a, miR-27b, let-7f, and miR-210 significantly increased
Cipollone et al. [33]	2011	Laboratory study	53 atherosclerotic plaques	miR-100, miR-127, miR-145, miR-133a, and miR-133b were more expressed in symptomatic versus asymptomatic plaques
Devaux et al. [36]	2015	Clinical study	224 patients with AMI	miR-208b, miR-499, and miR-320a were significantly higher in patients with AMI
Wang et al. [37]	2010	Clinical study	66 patients	miR-1, miR-133a, miR-499, and miR-208a in AMI
			33 AMI, 33 non-AMI with chest pain and distress
Li et al. [38]	2013	Clinical study	67 patients with AMI	miR-1, miR-133a, miR-208b, and miR-499 in AMI < 0.001
Yao et al. [39]	2014	Clinical study	30 on-pump patients after coronary artery bypass surgery	miR-499, ; miR-133a, ; miR-133b,