Research Article

Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats

Figure 4

Effects of ETN on neuronal apoptosis induced by cerebral ischemia in rat brains. Representative photomicrograph and apoptosis index showing terminal deoxyribonucleotidyl transferase-mediated biotin-16-dUTP nick end-labeling-positive cells in the penumbra cortex in the non-DM group (a) and DM group (b) treated with ETN before and after ischemia. The closed column is the vehicle group, and the open column is the ETN group. Scale bar = 100 μm. Data are the means ± SDs (–7). and 0.01 for statistical significance compared with the vehicle group. DM, diabetes mellitus; ETN, etanercept.
(a) Non-DM
(b) DM