Review Article
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head
Table 1
General characteristics of the studies included in the present meta-analysis.
| ID | Study | Publication year | Ethnicity (country) | Control source | Genotyping methods | Sample size | Case | Control |
| 1 | Glueck et al. [23] | 1999 | Caucasian (USA) | Healthy subjects | PCR-RFLP | 59 | 234 | 2 | Glueck et al. [14] | 2001 | Caucasian (USA) | Healthy subjects | PCR-RFLP | 36 | 235 | 3 | Kutlar et al. [16] | 2001 | Caucasian (USA) | ONFH-free subjects | PCR-RFLP | 45 | 62 | 4 | Zalavras et al. [24] | 2002 | Caucasian (Greece) | Healthy subjects | PCR-RFLP | 66 | 300 | 5 | Bernbeck et al. [17] | 2003 | Caucasian (Germany) | NS | NS | 14 | 73 | 6 | Asano et al. [18] | 2004 | Asian (Japan) | ONFH-free subjects | DS | 31 | 106 | 7 | Celik et al. [25] | 2006 | Caucasian (Turkey) | ONFH-free subjects | PCR-RFLP | 11 | 39 | 8 | Chang et al. [26] | 2008 | Asian (Korea) | Healthy subjects | Multiplex PCR | 71 | 200 | 9 | Liu et al. [27] | 2009 | Asian (China) | Healthy subjects | PCR-RFLP | 89 | 77 | 10 | Kim et al. [28] | 2010 | Asian (Korea) | ONFH-free subjects | TaqMan | 438 | 269 | 11 | Gagala et al. [29] | 2013 | Caucasian (Poland) | Healthy subjects | PCR-RFLP | 68 | 100 | 12 | Li et al. [15] | 2013 | Asian (China) | Healthy subjects | PCR-RFLP | 93 | 83 |
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PCR-RFLP-polymerase chain reaction-restriction fragment length polymorphism, NS-data not shown, DS-direct sequencing.
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