BioMed Research International / 2015 / Article / Tab 1

Review Article

Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head

Table 1

General characteristics of the studies included in the present meta-analysis.

IDStudyPublication yearEthnicity (country)Control source Genotyping methodsSample size

1Glueck et al. [23]1999Caucasian (USA) Healthy subjects PCR-RFLP59234
2Glueck et al. [14]2001Caucasian (USA)Healthy subjectsPCR-RFLP36235
3Kutlar et al. [16]2001Caucasian (USA)ONFH-free subjectsPCR-RFLP4562
4Zalavras et al. [24]2002Caucasian (Greece)Healthy subjectsPCR-RFLP66300
5Bernbeck et al. [17]2003Caucasian (Germany)NSNS1473
6Asano et al. [18]2004Asian (Japan)ONFH-free subjectsDS31106
7Celik et al. [25]2006Caucasian (Turkey)ONFH-free subjectsPCR-RFLP1139
8Chang et al. [26]2008Asian (Korea)Healthy subjectsMultiplex PCR71200
9Liu et al. [27]2009Asian (China)Healthy subjectsPCR-RFLP8977
10Kim et al. [28]2010Asian (Korea)ONFH-free subjectsTaqMan438269
11Gagala et al. [29]2013Caucasian (Poland)Healthy subjectsPCR-RFLP68100
12Li et al. [15]2013Asian (China)Healthy subjectsPCR-RFLP9383

PCR-RFLP-polymerase chain reaction-restriction fragment length polymorphism, NS-data not shown, DS-direct sequencing.

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