BioMed Research International / 2015 / Article / Tab 4 / Review Article
The Role of Enteral Nutrition in Patients with Inflammatory Bowel Disease: Current Aspects Table 4 (a) Comparison of elemental versus nonelemental diets in patients with Crohn’s disease. (b) Enteral nutrition versus corticosteroids in patients with active Crohn’s disease.
(a)
Author/reference
Total number of patients
Treatment’s duration Short-term remission Long-term remission
Conclusion Non-ED (rate of remission) ED (rate of remission) Non-ED (rate of remission) ED (rate of remission) Rigaud et al. [31 ] 30 6 weeks (short-term) 11/15 (73%) 10/15 (67%) 4/15 (27%) 3/15 (2%) EN (non-ED or ED) is an efficient therapy for active CD. EN does not influence the long term outcome Verma et al. [32 ] 21 6 weeks 6/11 (55%) 8/10 (80%) — — EN is effective in treatment of active CD Polymeric and elemental diets are equally effective Giaffer et al. [33 ] 30 4 weeks 5/14 (36%) 12/16 (75%) — — ED offers significantly better short-term results compared to polymeric (non-elemental) diet in patients with acute exacerbations of CD
Non-ED = non-elemental diet, ED = elemental diet. (b)
Author/reference
Total patients’ number
Treatment’s duration Short-term remission Long-term remission
Conclusion Steroids (remission rate) Enteral (* ) nutrition (remission rate) Steroids (remission rate) Enteral (* ) nutrition (remission rate) Morain et al. [25 ] 21 4 weeks (short-term) and 12 weeks (long-term) 8/10 (80%) 9/11 (82%) 7/10 (70%) 8/11 (73%) EN is effective as CSs in inducing remission Malchow et al. [24 ] 95 6 weeks 32/44 (73%) 21/51 (41%) — — Drug combination was superior to EN in short-term remission Lochs et al. [23 ] 107 6 weeks 41/52 (79%) 29/55 (53%) — — EN is less effective than a combination of CSs and sulfasalazine in short-term remission Gorard et al. [35 ] 33 12 weeks 17/20 (85%) 10/13 (77%) 6/19 (32%) 1/11 (9%) EN is equally effective in the short term as CSs in CD The relapse rate after EN was greater than after treatment with CSs Gonzalez-Huix et al. [37 ] 32 4 weeks (short-term) 15/17 (88%) 12/15 (81%) 7/17 (41%) 10/15 (67%) EN is as safe and effective as CSs in inducing short-term remission in active CD Lindor et al. [41 ] 19 4 weeks 7/10 (70%) 3/9 (33%) — — The often poorly tolerated EN should not be considered as a substitute for standard therapy with CSs in CD
