Cytotoxicity of Cyclodipeptides from Pseudomonas aeruginosa PAO1 Leads to Apoptosis in Human Cancer Cell Lines

Figure 1

Chemical structures of cyclodipeptides (CDPs) from bacteria. (a) Structures of CDPs synthesized by some bacterial species, modified from [9, 10]. (b) CDPs isolated from Pseudomonas aeruginosa strain PAO1. Isolation of CDPs was carried out according to the previously reported protocol [12]. A mixture of CDPs, mainly comprised of cyclo(L-Pro-L-Tyr), cyclo(L-Pro-L-Val), and cyclo(L-Pro-L-Phe) in a 1 : 1 : 1 molar ratio, was used in this study.

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