Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis

Table 1

Treatment recommendations for nontuberculous mycobacteria, according to 2007 American Thoracic Society Guidelines.

	Initial therapy for nodular/bronchiectatic disease	Initial therapy for cavitary disease	Severe disease or previously treated disease
Mycobacterium avium complex	Clarithromycin 1,000 mg TIW or azithromycin 500–600 mg TIW; Ethambutol 25 mg/kg TIW; Rifampin 600 mg TIW	Clarithromycin 500–1,000 mg/d or azithromycin 250–300 mg/d; Ethambutol 15 mg/kg/d; Rifampin 450–600 mg/d; ± Streptomycin or amikacin or none	Clarithromycin 500–1,000 mg/d or azithromycin 250–300 mg/d; Ethambutol 15 mg/kg/d; Rifabutin 150–300 mg/d or rifampin 450–600 mg/d; ± Streptomycin or amikacin
Mycobacterium kansasii	Rifampin 10 mg/kg/d (maximum 600 mg/day)
	Ethambutol 15 mg/kg/d
	Isoniazid 5 mg/kg/d (maximum 300 mg)
	Pyridoxine 50 mg/d

TIW: three times in a week; d: day.