Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 201587, 15 pages
http://dx.doi.org/10.1155/2015/201587
Research Article

Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder

1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
2Center of Excellence in Neuroscience and Department of Psychiatry, Paul L. Foster School of Medicine, Texas Tech University Health Science Center, El Paso, TX 79905, USA
3Department of Pediatrics, Paul L. Foster School of Medicine, Texas Tech University Health Science Center, El Paso, TX 79905, USA
4Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94103, USA
5Los Angeles Biomedical Research Center at Harbor, University of California Los Angeles Medical Center, Torrance, CA 90502, USA
6Instituto de Informacion de Investigacion en Salud Mental, 64710 Monterrey, NL, Mexico
7Medical and Family Research Group, Carracci S.C., 03740 Mexico City, DF, Mexico
8Centro Internacional de Trastornos Afectivos y de la Conducta Adictiva (CITACA), 01010 Guatemala City, Guatemala

Received 23 April 2014; Revised 16 September 2014; Accepted 18 September 2014

Academic Editor: Daniela Parolaro

Copyright © 2015 Yongsheng Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Figure S1: The DNA methylation landscape of bipolar disease.

Supplemental Figure S2: Genomic distribution of DMRs in bipolar disease.

Supplemental Figure S3: Ultra DMRs are associated with gene- and CGI-related regions.

Supplemental Figure S4: Ultra DMRs are associated with gene- and CGI-related regions in BP.

Supplemental Figure S5: Ultra DMRs are associated with gene- and CGI-related regions in SZ.

Supplemental Figure S6: Ultra DMRs are associated with long CGIs and HCPs.

Supplemental Figure S7: Common genes aberrant methylated in SZs and BPs.

Supplementary Table 1:The hypermethylated and hypomethylated promoters in SZs.

Supplementary Table 2:The Specific hypermethylated and hypomethylated promoters with distinct patterns in SZs.

Supplementary Table 3: The hypermethylated and hypomethylated promoters in BPs.

Supplementary Table 4: KEGG pathways enriched by aberrant methylated genes specifically in SZs/normal.

Supplementary Table 5: KEGG pathways enriched by aberrant methylated genes in BPs.

Supplementary Table 6: Aberrant hypermethylated HCP genes in SZs.

  1. Supplementary Material