Decorin-Mediated Inhibition of Human Trophoblast Cells Proliferation, Migration, and Invasion and Promotion of Apoptosis In Vitro

Figure 2

The migration and invasion capacity of trophoblast cells transfected with pEGFP-DCN and control. ((a) and (b)) HTR-8/SVneo cells treated with decorin overexpression presented significantly inhibited migration (a) and invasion (b) potentials compared to control. (c) The histogram showed the statistical data of (a) and (b). (d) The migration ability of JEG-3 cells treated with decorin overexpression was significantly lower than that of the control, as determined by transwell assays. (Values are mean ± SEM; ; .) (e) The invasion ability of JEG-3 cells treated with decorin overexpression was significantly lower than control. (f) The histogram showed the statistical data of (e) and (f). ((g) and (h)) Western blotting analysis of MMP2 and MMP9 protein in pEGFP-DCN or empty vector transfected HTR-8/SVneo and JEG-3 cells. (Values are mean ± SEM; ; .)