A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats

<div>Chemical structures of matrine and its derivatives, including M19 (C<sub>16</sub>N<sub>3</sub>H<sub>27</sub>S), and compound series. M19 was obtained through thiosulfate and side chain Michael addition, and the series of WM1, WM2, and WM3 were those containing an alkyl group or alkyl groups in place of one or more hydrogen atoms on M19. WM130 was obtained through reconstructing the structure of M19 with 18-methylamino-acylated and amino side chain addition.</div>

BioMed Research International

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Figure 1: A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats 

Figure 1 | A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats 