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BioMed Research International
Volume 2015 (2015), Article ID 204628, 11 pages
Research Article

Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study

1Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin 300052, China
2Tianjin Anning Hospital, Tianjin 300300, China

Received 2 August 2014; Revised 5 October 2014; Accepted 26 October 2014

Academic Editor: Yu-Feng Zang

Copyright © 2015 Yongjie Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Altered spontaneous brain activity as measured by ALFF, fALFF, and ReHo has been reported in schizophrenia, but no consensus has been reached on alternations of these indexes in the disorder. We aimed to clarify the regional alterations in ALFF, fALFF, and ReHo in schizophrenia using a meta-analysis and a large-sample validation. A meta-analysis of activation likelihood estimation was conducted based on the abnormal foci of ten studies. A large sample of 86 schizophrenia patients and 89 healthy controls was compared to verify the results of the meta-analysis. Meta-analysis demonstrated that the alternations in ALFF and ReHo had similar distribution in schizophrenia patients. The foci with decreased ALFF/fALFF and ReHo in schizophrenia were mainly located in the somatosensory cortex, posterior parietal cortex, and occipital cortex; however, foci with increased ALFF/fALFF and ReHo were mainly located in the bilateral striatum, medial temporal cortex, and medial prefrontal cortex. The large-sample study showed consistent findings with the meta-analysis. These findings may expound the pathophysiological hypothesis and guide future research.