Research Article

Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study

Table 1

The demographic and clinical data of studies included in the meta-analysis.

ReferencesPublication yearScannersIndices Patients
age (years)
Controls
age (years)
Patients
(cases/F)
Controls
(cases/F)
DiagnosisDuration of illnessPANSS totalPANSS positivePANSS negative

Hoptman et al. [13]2010Siemens 1.5TALFF/fALFF36.5 ± 11.041.9 ± 10.929/326/7CS13.0 ± 7.2 (years)76.5 ± 16.618.4 ± 6.220.2 ± 6.2
Huang et al. [14]2010GE 3TALFF24.2 ± 8.424.5 ± 8.666/3666/36FES8.8 ± 14.1 (months)107.2 ± 15.126.4 ± 5.220.7 ± 6.3
He et al. [15]2013GE 3TfALFF25.4 ± 8.326.6 ± 8.9104/55104/54FES39.5 ± 31.9 (weeks)92.1 ± 17.5
Ren et al. [16]2013GE 3TALFF24.3 ± 7.524.4 ± 7.6100/59100/59FES6.3 ± 11.0 (months)97.9 ± 17.825.1 ± 6.018.8 ± 7.7
Turner et al. [17]2013Siemens/GE 3TALFF/fALFF34.4–44.834.4–42.5146/35160/46CS13.1–24.1 (years)53.8–64.713.5–16.513.1–16.7
Yu et al. [18]2014Siemens 3TALFF/fALFF31.7 ± 9.629.9 ± 8.669/3562/27CS7.1 ± 6.5 (years)52.9 ± 16.812.1 ± 4.713.4 ± 6.1
Liu et al. [19]2006GE 1.5TReHo23.7 ± 4.424.4 ± 3.918/918/9Mixed26.8 ± 19.2 (months)80.4 ± 18.7
Jiang et al. [20]2010GE 1.5TReHo16.4 ± 0.816.3 ± 0.918/918/9EOS9.6 ± 5.9 (months)91.8 ± 6.7
Chen et al. [21]2013Siemens 3TReHo28.3 ± 1.4335.7 ± 1.836/2044/27FES25.2 ± 6.9
Yu et al. [22]2013Siemens 3TReHo31.7 ± 9.629.9 ± 8.669/3662/27CS7.1 ± 6.5 (years)52.9 ± 16.812.1 ± 4.713.4 ± 6.1

Turner et al. [17] present the demographic information in 7 sites, respectively. Thus we only show the ranges of mean values from the 7 sites.
All studies did not give the medication information except for the study of Hoptman et al. [13], so we did not list the information in the table.
F, female; PANSS, Positive and Negative Syndrome Scale; FES, first-episode schizophrenia; CS, chronic schizophrenia; Mixed, FES and CS; EOS, early onset schizophrenia.