Network Comparison of Inflammation in Colorectal Cancer and Alzheimer’s Disease

Table 1

Inflammation-associated genes common to both AD and CRC show opposite expression patterns. The 16 oppositely expressed common genes (in Figure 1(b)) between AD and CRC were assigned to inflammation-associated functional terms in IPA.

Functional category	Downregulated in AD and upregulated in CRC	Upregulated in AD and downregulated in CRC
Chemokine	PTPN6, IRAK3, FLT3	BAD, CD36
Inflammation relating to CRC	DDIT3, FAS, IRF3
Inflammation relating to brain	CCR6, CD28, DDIT3, FAS, FCER1G, NGFR	PPARD
Cytokines relating to cancer	CD28, FN1	ABL1, EGFR
Cytokines relating to brain		CD36

Genes detected in the CRC network from GSE4107 dataset.
Genes detected in the AD network from GSE1297 dataset.
^#Genes detected in the AD network from GSE12685 dataset.