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Subgroup of chemicals | Environmental chemical | TIDM epidemiology | TIDM animal studies | T2DM epidemiology | Beta-cell modulations | Immuno modulations | Likelihood for T1DM influence |
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Polychlorinated biphenyls | PCB | + Longnecker et al. 2001 [16] | | + Everett et al. 2011 [22] | | + Schmidt and Bradfield 1996 [23] | +++ (−) |
+ Langer et al. 2002 [18] | | + Carpenter 2006 [21] | | | |
− Rignell-Hydbom et al. 2010 [17] | | | | | |
Dioxins | TCDD/dioxin | | − Shinomiya et al. 2000 [28] | + Cranmer et al. 2000 [39] | + Martino et al. 2013 [25] | − Rohlman et al. 2012 [30] | ++ (−) |
| − Kerkvliet et al. 2009 [29] | + Pelclová et al. 2006 [40] | + Kurita et al. 2009 [26] | − Li and McMurray 2009 [33] − Schulz et al. 2012a, b [34, 35] | |
| | − Warner et al. 2013 [41] | + Kim et al. 2009 [27] | − Hanieh 2014 [32] | |
| | | | + Ishimaru et al. 2009 [36] | |
| | | | + Mustafa et al. 2011a, b [37, 38] | |
Organochlorides (pesticides) | DDT/DDE | − Rignell-Hydbom et al. 2010 [17] | | + Codru et al. 2007 [43] | | + Yang et al. 2012 [44] | ++ (−) |
| | + Philibert et al. 2009 [45] | | − Li and McMurray 2009 [33] | |
| | + Taylor et al. 2013 [46] | | | |
| | + Turyk et al. 2009 [47] | | | |
Polybrominated biphenyls (Flame retardants) | PDBE | | | + Lee et al. 2011 [48] | + Zhang et al. 2013 [49] | + Hennigar et al. 2012 [50] | ++ |
| | − Turyk et al. 2009 [47] | | + Turyk et al. 2008 [51] | |
| | + Llm et al. 2008 [52] | | | |
Perfluorinated alkyl substances | PFAS | | | + Lind et al. 2014 [53] | + Lin et al. 2009 [54] | + Grandjean et al. 2012 [55] | ++ |
| | | + Lv et al. 2013 [56] | + Granum et al. 2013 [57] | |
| | | | + Borg et al. 2013 [58] | |
|
Endocrine disruptors | BPA | | + Bodin et al. 2013 [59]; Bodin et al. 2014 [60] | + Aekplakorn et al. 2014 [61] | + Song et al. 2012 [62] | + Bodin et al. 2014 [60] | ++++ |
| | + Ahmadkhaniha et al. 2014 [63] | + Soriano et al. 2012 [64] | | |
| | − Kim and Park 2013 [65] | + Nadal et al. 2009 [66] | | |
| | + Sabanayagam et al. 2013 [67] | | | |
| | + Shankar and Teppala 2011 [68] | | | |
| | + Silver et al. 2011 [69] | | | |
| | + Sun et al. 2014 [70] | | | |
Triclosan | | | | | + Paul et al. 2009 [71] | + |
| | | | + Zorrilla et al. 2009 [72] | |
| | | | + Koeppe et al. 2013 [73] | |
Phthalates | | | + Huang et al. 2014 [74] | | + Mankidy et al. 2013 [75] | + |
| | + James-Todd et al. 2012 [76] | | + Vetrano et al. 2010 [77] | |
| | + Kim et al. 2013 [78] | | + Sarath Josh et al. 2014 [79] | |
| | + Lind et al. 2012 [80] | | | |
| | + Stahlhut et al. 2007 [81] | | | |
| | + Svensson et al. 2011 [82] | | | |
| | + Trasande et al. 2013 [83] | | | |
|
Metals | Arsenic | | | + Rager et al. 2014 [84] | + Douillet et al. 2013 [85] | + Dangleben et al. 2013 [86] | ++ |
| | + Tsai et al. 1999 [87] | + Lu et al. 2011 [88] | + Ahmed et al. 2012 [89] | |
| | + Bräuner et al. 2014 [90] | + Yang et al. 2012 [44] | + Banerjee et al. 2009 [91] | |
| | + Lee and Kim 2013 [92] | | + Lu et al. 2014 [93] | |
| | + Mahram et al. 2013 [94] | | | |
| | | | | |
Organotins | | | | + Miura et al. 1997 [95]; Miura et al. 2012 [96] | | + |
| | | + Zuo et al. 2014 [97] | | |
| | | − Matsui et al. 1984 [98] | | |
|
Nitroso compounds | Nitrates and nitroso amines | + Dahlquist et al. 1990 [99] | | | + Helgason and Jonasson 1981 [100] | | ++ (+) |
+ Benson et al. 2010 [101] | | | + Wilson et al. 1983 [102] | | |
− Samuelsson et al. 2011 [103] | | | | | |
− Cherian et al. 2010 [104] | | | | | |
(+) Kostraba et al. 1992 [105] | | | | | |
(+) Parslow et al. 1997 [106] | | | | | |
(+) van Maanen et al. 1999 [107] | | | | | |
(+) Helgason 1991 | | | | | |
Streptozotocin | | + Szkudelski 2001 [108] | | + Schnedl et al. 1994 [109] | | ++ |
| + Leiter 1982 [110] | | + Wang and Gleichmann 1998 [111] | | |
| + Rossini et al. 1977 [112] | | + Lenzen 2008 [11] | | |
Alloxan | | + Rerup 1970 [113] | | + Lenzen 2008 [11] | | ++ |
| | | + Szkudelski 2001 [108] | | |
| | | + Eizirik et al. 1994 [114] | | |
Bafilomycin | | + Hettiarachchi et al. 2004 [115] | | + Myers et al. 2003 [116] | | ++ |
| | | + Hettiarachchi et al. 2006 [117] | | |
Vacor | | | | + Myers et al. 2003 [116] | | + |
| | | + Esposti et al. 1996 [118] | | |
| | | + Taniguchi et al. 1989 [119] | | |
| | | + Wilson and Gaines 1983 [120] | | |
Cereulides | | | | + Virtanen et al. 2008 [121] | | + |
| | | + Vangoitsenhoven et al. 2014 [122] | | |
|
Air pollution | Particulate matter | | | + Eze et al. 2014 [123] | | + Danielsen et al. 2011 [124] | ++ |
| | + Hathout et al. 2001 [125] | | + den Hartigh et al. 2010 [126] | |
| | + Brook et al. 2013 [127] | | + Yan et al. 2011 [128] | |
Ozone | + Hathout et al. 2006 [129] | | | | + Bass et al. 2013 [130] | +++ |
Carbon monoxide | | | + Janghorbani et al. 2014 [131] | | | + |
| | + Dales et al. 2012 [132] | | | |
| | − Nikolic et al. 2014 [133] | | | |
Maternal/smoking | + Hathout et al. 2006 [129] | | + Thiering et al. 2011 [134] | + Rasouli et al. 2013 [135] | | +++ (−) |
− Dahlquist and Kallen 1992 [136] | | + Persson et al. 2000 [137] | | | |
− Hjern and Söderström 2008 [138] | | | | | |
− Ievins et al. 2007 [139] | | | | | |
− Johansson et al. 2008 [140] | | | | | |
− Marshall et al. 2004 [141] | | | | | |
− Rasouli et al. 2013 [135] | | | | | |
− Robertson and Harrild 2010 [142] | | | | | |
PAH | | | + Zhao et al. 2014 [183] | | + Nadeau et al. 2010 [144] | ++ |
polycyclic aromatic hydrocarbon | | | | | + den Hartigh et al. 2010 [126] | |
| | | | + Danielsen et al. 2011 [124] | |
| | | | + Perreault et al. 2013 [145] | |
|