Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis

Table 3

Effect of icodextrin use on lipid profiles (RCT and cohort studies).

Factor	Number of studies	Heterogeneity test				Weighted mean difference
				value	Model of meta	Mean	[95% CI]	value
Total cholesterol (mmol/L)	7	3.70	46.10%	0.190	F			<0.001
Triglycerides (mmol/L)	6	21.02	76.20%	0.001	R			0.206
HDL-C (mmol/L)	4	7.41	59.50%	0.06	R			0.245
LDL-C (mmol/L)	4	9.87	69.60%	0.02	R			0.922
VLDL-C (mmol/L)	2	0.09	<0.01%	0.762	F			0.529
Free fatty acid (mol/L)	2	0.04	<0.01%	0.845	F			0.004
Lipoprotein(a) (mg/dL)	2	8.69	88.50%	0.003	R			0.481

Note: the value was less than 0.05, and the WMD was considered statistically significant.
Model of meta: F: Fixed, R: Random.