Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae)

Table 3

Main constituents of leaf extract and fractions from Croton sphaerogynus leaves and respective GC/EIMS data. EE: crude EtOH extract; MP: methanol phase; HP: hexane phase; F1: fraction 1. RT: retention time (min); MM: molecular mass; N.I.: not identified.

	RT (min)	MM	Characterizatio	Relative amount (%)
				Dc	Me	EE	MP	HP	F1
1	14.8	272	Abieta-8, 11-diene	2.2	2.3	—	—	3.8	—
2	15.2	278	NI			—	0.9	1.6	—
3	16.2	306	NI			—	—	1.3	—
4	16.4	286	Abieta-8,11-dien-3-one	20.2	20.1	36.0	22.3	27.6	23.8
5	16.7	286	Abieta-8,11,13-trien-3-ol	6.2	13.1	5.4	6.5	7.7	7.1
6	16.9	288	Abieta-8,11-dien-3-ol	3.8	16.7	4.6	8.0	3.3	8.9
7	17.2	286	Podocarp-7-en,13-methyl-13-vinyl-3-one	12.9	4.7	11.2	17.9	18.5	17.9
8	17.5	286	NI			2.1	2.5	0.9	2.7
9	17.7	288	NI			0.9	3.8	1.5	4.6
10	18.0	284	NI			3.6	1.7	1.6	1.4
11	18.1	286	NI			—	1.3	1.8	1.6
12	18.2	286	NI			6.7	4.0	3.3	3.4
13	18.6	286	Abieta-8,11,13-trien-12-ol	11.9	18.5	10.3	13.9	21.8	13.5
14	19.2	288	Podocarp-7-en-3-ol, 13-methyl-13-vinyl	4.5		1.6	6.2	4.0	6.0
15	19.3	302	13-hydroxy-abieta-8,11-dien-7-one	4.8		4.2	2.1	—	1.9
16	20.3	300	11-hydroxy-abieta-8,11,13-trien-7-one	3.4		2.2	0.9	—	1.2
17	20.5	302	NI			—	1.2	—	1.3
18	20.6	300	Abieta-6,8,11,13-tetraen-3,12-diol	0.7		10.2	4.8	0.7	4.2
19	21.1	286	NI			—	1.2	—	0.4
20	21.2	302	Abieta-8,11,13-trien-6,14-diol	0.8		0.9	0.9	—	—
21	—	316	Crotonin derivativ	5.2		—	—	—	—
NI				23.4	24.6	8.8	9.7	7.1	7.8

Main constituents of leaf extract of Croton sphaerogynus and respective GC/EIMS data and characterization according to Motta et al. [20]. Dch, CH₂Cl₂; Met, MeOH.