ProSim: A Method for Prioritizing Disease Genes Based on Protein Proximity and Disease Similarity

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/213750/figures/213750.fig.004a.svgz" name="213750.fig.004a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Breast cancer</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/213750/figures/213750.fig.004b.svgz" name="213750.fig.004b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Alzheimer disease</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/213750/figures/213750.fig.004c.svgz" name="213750.fig.004c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b>Colorectal cancer</td></tr><tr class="fig-image" id="d"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/213750/figures/213750.fig.004d.svgz" name="213750.fig.004d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(d) </b>Diabetes mellitus</td></tr><tr class="fig-image" id="e"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/213750/figures/213750.fig.004e.svgz" name="213750.fig.004e" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(e) </b>Lung cancer</td></tr><tr class="fig-image" id="f"><td><object data="https://static.hindawi.com/articles/bmri/volume-2015/213750/figures/213750.fig.004f.svgz" name="213750.fig.004f" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(f) </b>Prostate cancer</td></tr></table>

<div>Comparison of top ten genes as a Venn diagram. Blue, orange, red, and black circles represent ProSim, PRINCE, RWR, and DADA methods, respectively. (a) Breast cancer. (b) Alzheimer disease. (c) Colorectal cancer. (d) Diabetes mellitus. (e) Lung cancer. (f) Prostate cancer.</div>

BioMed Research International

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Figure 4: ProSim: A Method for Prioritizing Disease Genes Based on Protein Proximity and Disease Similarity 