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BioMed Research International
Volume 2015, Article ID 231782, 8 pages
Research Article

The Role of Contrast-Enhanced Ultrasound in Selection Indication and Improveing Diagnosis for Transthoracic Biopsy in Peripheral Pulmonary and Mediastinal Lesions

1Key Laboratory of Carcinogensis and Translational Research of Ministry of Education, Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China
2Department of Ultrasound, Harbin First Hospital, Harbin, Heilongjiang 150010, China

Received 8 August 2014; Accepted 2 October 2014

Academic Editor: Hui-Xiong Xu

Copyright © 2015 Song Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the value of contrast-enhanced ultrasound (CEUS) in transthoracic biopsy of peripheral lung and mediastinal lesions. Methods. Of 142 patients, 82 patients received CEUS before biopsy and were defined as CEUS group. The remaining 60 patients only underwent conventional ultrasound (US) before biopsy and were served as US group. The information of CEUS was used for selecting indication and instructing biopsy. The imaging features, number of punctures, diagnostic successful rate, and complication rate between the two groups were compared. Results. Necrosis was demonstrated in 43.9% of the lesions in CEUS group and in 6.7% of US group (). Detection rate of lesion hidden in pulmonary atelectasis in CEUS group was 13.4%, which was statistically higher than 1.7% of US group (). The diagnostic success rate was 96.3% for CEUS group and 80% for US group, respectively (). The average number of punctures was and , respectively. There was no significant difference in complications between CEUS group and US group. Conclusions. CEUS could play an important role in selecting proper indication and improving diagnostic accuracy rate of lung biopsy.