Direct Effects of (−)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria

<div>Effect of (−)-epicatechin (<b>1</b>) on the cytochrome <svg height="6.42315pt" id="M29" style="vertical-align:-0.2129903pt" version="1.1" viewbox="-0.0498162 -6.21016 5.62081 6.42315" width="5.62081pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M383 397C383 424 344 448 299 448C244 448 172 409 132 375C66 319 23 227 23 146C23 42 74 -12 146 -12C208 -12 298 30 359 103L343 124C315 95 248 48 192 48C145 48 111 85 111 163C111 228 129 294 151 330C171 363 201 401 241 401C275 401 302 384 325 356C332 347 339 344 348 348C373 360 383 381 383 397Z" id="g113-100"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="406" vert-adv-y="406"></glyph.data></g></svg> release from isolated rat heart mitochondria oxidizing succinate in the presence of amytal. <svg height="14.6424pt" id="M30" style="vertical-align:-5.760039pt" version="1.1" viewbox="-0.0498162 -8.88236 55.4503 14.6424" width="55.4503pt" 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vert-adv-y="411"></glyph.data></g></svg>, cytochrome <svg height="6.42315pt" id="M31" style="vertical-align:-0.2129903pt" version="1.1" viewbox="-0.0498162 -6.21016 5.62081 6.42315" width="5.62081pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M383 397C383 424 344 448 299 448C244 448 172 409 132 375C66 319 23 227 23 146C23 42 74 -12 146 -12C208 -12 298 30 359 103L343 124C315 95 248 48 192 48C145 48 111 85 111 163C111 228 129 294 151 330C171 363 201 401 241 401C275 401 302 384 325 356C332 347 339 344 348 348C373 360 383 381 383 397Z" id="g113-100"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="406" vert-adv-y="406"></glyph.data></g></svg> (32 <i>μ</i>M), stimulated State 3 respiration rate of heart mitochondria, V<sub>ADP</sub>, State 3 respiration rate of heart mitochondria. <svg height="14.52pt" id="M32" style="vertical-align:-3.993601pt" version="1.1" viewbox="-0.0498162 -10.5264 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id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus control, <svg height="8.66698pt" id="M33" style="vertical-align:-0.2129993pt" version="1.1" viewbox="-0.0498162 -8.45398 29.0065 8.66698" width="29.0065pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g><g 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The results were analysed with one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test.</div>

BioMed Research International

fig4

Figure 4

Figure 4: Direct Effects of (−)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria 