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BioMed Research International
Volume 2015 (2015), Article ID 237507, 6 pages
http://dx.doi.org/10.1155/2015/237507
Review Article

Past, Present, and Future of Nerve Conduits in the Treatment of Peripheral Nerve Injury

1Medical Center, Tsinghua University, Beijing 8610084, China
2Department of Orthopedics, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 86838010, China
3Institute of Tissue Engineering, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 86110122, China

Received 12 February 2015; Revised 12 May 2015; Accepted 19 May 2015

Academic Editor: Aijun Wang

Copyright © 2015 Aikeremujiang Muheremu and Qiang Ao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

With significant advances in the research and application of nerve conduits, they have been used to repair peripheral nerve injury for several decades. Nerve conduits range from biological tubes to synthetic tubes, and from nondegradable tubes to biodegradable tubes. Researchers have explored hollow tubes, tubes filled with scaffolds containing neurotrophic factors, and those seeded with Schwann cells or stem cells. The therapeutic effect of nerve conduits is improving with increasing choice of conduit material, new construction of conduits, and the inclusion of neurotrophic factors and support cells in the conduits. Improvements in functional outcomes are expected when these are optimized for use in clinical practice.