Table 1: The major part of our previous studies about immunological effects of asbestos exposure and analysis for immune functions of patients.

Analyses forAsbestos in cultures or name of diseasesResultsReferences

(i) Natural killer (NK) cells
Human NK cell line, YT-A1Culture with chrysotileDecreases in natural cytotoxicity, cell surface NKG2D, and 2B4 and phosphorylation of ERK[5, 6]
Peripheral blood CD56+ NK cellsMalignant mesotheliomaLow cytotoxicity, low expression of cell surface NKp46[5]
Human NK cells in PBMCCulture with chrysotileDecrease in cell surface NKp46[5]

(ii) T helper cells
Human T cell line, MT-2Culture with chrysotileResistance against asbestos-induced apoptosis, increases in secretion of IL-10 and expression of bcl-2 mRNA, decreases in secretion of IFN-, TNF-, IL-6, and CXCL10, and surface expression and mRNA of CXCR3[1, 2]
Culture with crocidoliteResistance against asbestos-induced apoptosis, increases in secretion of IL-10 and ratio of bcl-2/bax mRNAs, and decreases in secretion of IFN- and TNF-[4]
Peripheral blood CD4+ T cellsMalignant mesotheliomaVery low expression of cell surface CXCR3, low IFN- mRNA, and high bcl-2 mRNA[1, 3]
Pleural plaqueLow expression of cell surface CXCR3 [3]
Isolated human CD4+ T cellsCulture with chrysotileDecreases in cell surface CXCR3 and intracellular IFN-[3]

(iii) Cytotoxic T lymphocytes (CTL)
Human CD8+ T cells in mixed lymphocyte reactionCulture with chrysotileDecreases in allogeneic cytotoxicity and intracellular IFN- and granzyme B[7]
Peripheral blood CD8+ T cellsMalignant mesotheliomaHigh percentage of perforin+ cells, stimulation-induced decrease in perforin+ cells[9]
Pleural plaqueHigh percentage of perforin+ cells[9]