Review Article

A Survey on the Computational Approaches to Identify Drug Targets in the Postgenomic Era

Figure 2

A schematic view of identifying drug-target interaction from molecular networks. (a) Identify drug targets from PPIN supposing that proteins in close proximity of the PPIN are more likely targeted by the same drug(s). (b) Predict drug targets based on metabolic networks assuming that the targets are able to interrupt the pathological procedure so that the disease status can be reversed to normal status.