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BioMed Research International
Volume 2015, Article ID 241983, 10 pages
Research Article

Downregulation of Heparanase Expression Results in Suppression of Invasion, Migration, and Adhesion Abilities of Hepatocellular Carcinoma Cells

Department of Hepatobiliary Surgery, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, China

Received 11 August 2015; Revised 31 October 2015; Accepted 3 November 2015

Academic Editor: Shinichi Aishima

Copyright © 2015 Xiao-Peng Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

The following is the list of published articles that have cited the current article.

  • Kun Huang, Ju Liu, Hui Zhang, Jiliang Wang, and Huili Li, “Intramyocardial Injection of siRNAs Can Efficiently Establish Myocardial Tissue-Specific Renalase Knockdown Mouse Model,” BioMed Research International, vol. 2016, 2016. View at Publisher · View at Google Scholar
  • Shengjin Yu, Huiming Lv, He Zhang, Yu Jiang, Yu Hong, Rongjun Xia, Qifang Zhang, Weiwei Ju, Lili Jiang, Geng Ou, Jinhui Zhang, Shujing Wang, and Jianing Zhang, “Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway,” Biochemical and Biophysical Research Communications, vol. 485, no. 2, pp. 432–439, 2017. View at Publisher · View at Google Scholar
  • Xiaopeng Chen, Wen Jiang, Dafei Dai, Bin Cheng, Chen Huang, Linming Lu, Chaofu Yue, Wenjun Zhang, and Chaogang Tong, “Heparanase contributes to trans-endothelial migration of hepatocellular carcinoma cells,” Journal of Cancer, vol. 8, no. 16, pp. 3309–3317, 2017. View at Publisher · View at Google Scholar
  • Lin Zhang, Shaofeng Yang, and Nan Sheng, “MicroRNA-429 decreases the invasion ability of gastric cancer cell line BGC-823 by downregulating the expression of heparanase,” Experimental and Therapeutic Medicine, vol. 15, no. 2, pp. 1927–1933, 2018. View at Publisher · View at Google Scholar
  • Guanglu Che, Yanyun Wang, Bin Zhou, Linbo Gao, Tao Wang, Fang Yuan, and Lin Zhang, “Knockdown of Heparanase Suppresses Invasion of Human Trophoblasts by Activating p38 MAPK Signaling Pathway,” Disease Markers, vol. 2018, pp. 1–10, 2018. View at Publisher · View at Google Scholar