TY - JOUR A2 - Cama, Giuseppe AU - Bernardeschi, Daniele AU - Nguyen, Yann AU - Russo, Francesca Yoshie AU - Mosnier, Isabelle AU - Ferrary, Evelyne AU - Sterkers, Olivier PY - 2015 DA - 2015/10/04 TI - Cutaneous and Labyrinthine Tolerance of Bioactive Glass S53P4 in Mastoid and Epitympanic Obliteration Surgery: Prospective Clinical Study SP - 242319 VL - 2015 AB - Objective. To evaluate the cutaneous and the inner ear tolerance of bioactive glass S53P4 when used in the mastoid and epitympanic obliteration for chronic otitis surgery. Material and Methods. Forty-one cases have been included in this prospective study. Cutaneous tolerance was clinically evaluated 1 week, 1 month, and 3 months after surgery with a physical examination of the retroauricular and external auditory canal (EAC) skin and the presence of otalgia; the inner ear tolerance was assessed by bone-conduction hearing threshold 1 day after surgery and by the presence of vertigo or imbalance. Results. All surgeries but 1 were uneventful: all patients maintained the preoperative bone-conduction hearing threshold except for one case in which the round window membrane was opened during the dissection of the cholesteatoma in the hypotympanum and this led to a dead ear. No dizziness or vertigo was reported. Three months after surgery, healing was achieved in all cases with a healthy painless skin. No cases of revision surgery for removal of the granules occurred in this study. Conclusion. The bioactive glass S53P4 is a well-tolerated biomaterial for primary or revision chronic otitis surgery, as shown by the local skin reaction which lasted less than 3 months and by the absence of labyrinthine complications. SN - 2314-6133 UR - https://doi.org/10.1155/2015/242319 DO - 10.1155/2015/242319 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -